Estrogen inhibits starvation‐induced apoptosis in osteocytes by a redox‐independent process involving association of JNK and glutathione S‐transferase P1‐1
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DOI: 10.1002/2211-5463.12216
Abstract: Estrogen deficiency causes bone loss as a result of microdamage, oxidative stress, and osteocyte apoptosis. A relationship between oxidative stress‐induced apoptosis, c‐Jun N‐terminal kinase (JNK) activation, and expression of factors involved in bone remodeling has… read more here.
Keywords: starvation induced; apoptosis; jnk; induced apoptosis ... See more keywords
Targeting GSTP1 as Therapeutic Strategy against Lung Adenocarcinoma Stemness and Resistance to Tyrosine Kinase Inhibitors
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DOI: 10.1002/advs.202205262
Abstract: Glutathione S‐transferase pi (GSTP1), a phase II detoxification enzyme, is known to be overexpressed and mediates chemotherapeutic resistance in lung cancer. However, whether GSTP1 supports cancer stem cells (CSCs) and the underlying mechanisms in lung… read more here.
Keywords: lung adenocarcinoma; lung; tyrosine kinase; resistance ... See more keywords
Pi‐Class Glutathione S‐transferase (GSTP1)‐Selective Fluorescent Probes for Multicolour Imaging with Various Cancer‐Associated Enzymes
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200443
Abstract: Pi‐class glutathione S‐transferase (GSTP1) is highly expressed in a wide variety of human cancer tissues compared to the corresponding normal counterpart. Therefore, GSTP1 is a potential target enzyme for overcoming resistance to chemotherapeutic agents or… read more here.
Keywords: cancer; cancer associated; class glutathione; fluorescent probes ... See more keywords
Long intergenic noncoding RNA 00844 promotes apoptosis and represses proliferation of prostate cancer cells through upregulating GSTP1 by recruiting EBF1
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29690
Abstract: Accumulating evidence have suggested the function of long noncoding RNAs as crucial players in the pathogenesis of prostate cancer (PC), a urologic tumor in male with poor prognosis. This study was designed to explore the… read more here.
Keywords: long intergenic; noncoding rna; gstp1; prostate cancer ... See more keywords
Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes
Sign Up to like & getrecommendations! Published in 2018 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-018-3859-0
Abstract: Due to their wide applications, concern exists regarding possible genotoxic effects of inhalational anesthetics (IAs) among operating room personnel. This study was undertaken to examine genotoxic properties of co-exposure to nitrous oxide, sevoflurane, and isoflurane… read more here.
Keywords: gstt1 gstm1; gstp1; gstt1; inhalational anesthetics ... See more keywords
Glutathione S-transferases P1-mediated interleukin-6 in tumor-associated macrophages augments drug-resistance in MCF-7 breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114289
Abstract: Glutathione S-transferase P1 (GSTP1), a phase II detoxifying enzyme, is overexpressed and plays an important role during breast cancer drug resistance. Tumor-associated macrophages (TAMs), representing most of the leukocyte population in solid tumors, are involved… read more here.
Keywords: drug resistance; gstp1; breast cancer; resistance ... See more keywords
Fluorescein diacetate (FDA) and its analogue as substrates for Pi-class glutathione S-transferase (GSTP1) and their biological application.
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DOI: 10.1016/j.talanta.2017.12.010
Abstract: Pi class glutathione S-transferase (GSTP1) is highly expressed in various cancerous cells and pre-neoplastic legions, where it is involved in apoptotic resistance or metabolism of several anti-tumour chemotherapeutics. Therefore, GSTP1 is a marker of malignant… read more here.
Keywords: transferase gstp1; gstp1; class glutathione; fluorescein ... See more keywords
A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2000361117
Abstract: Significance A strategy to overcome therapeutic obstacles of mKRAS and mBRAF cancers is devised based on the finding, here, that the RAF/MEK/ERK cascade is by-passed by an autocrine signal loop established by interaction of CRAF… read more here.
Keywords: craf; mkras mbraf; gstp1; craf glutathione ... See more keywords
GPX1 Pro198Leu polymorphism and GSTP1 Ile105Val polymorphisms are not associated with the risk of schizophrenia in the Chinese Han population
Sign Up to like & getrecommendations! Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000870
Abstract: Increasing lines of evidence show that oxidative stress plays a role in the pathophysiological mechanisms of schizophrenia (SCZ). Polymorphic variants of oxidative stress-related candidate genes GPX1 and GST1 can affect the antioxidant activities of their… read more here.
Keywords: chinese han; gstp1; schizophrenia chinese; han population ... See more keywords
Abstract LB-389: miR133a-3p sensitizes breast cancer cells by targeting GSTP1
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-lb-389
Abstract: Breast cancer is a main threat for women9s health and mammary carcinogenesis is attributed to estrogen receptor α (ERα)-mediated signaling pathways. Tamoxifen is one of the most effective ERα-targeting antiestrogen therapies to treat breast cancer.… read more here.
Keywords: gstp1; cancer cells; breast cancer; mir133a ... See more keywords
AA Homozygous Genotype of GSTP1 I105V Polymorphism in Oral Cancer: In Silico Screening, Molecular Dynamics Simulation and Activity Studies of Wild and Mutant GSTP1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Global Oncology"
DOI: 10.1200/jgo.18.33900
Abstract: Background: Highest incidence of oral squamous cell carcinoma (OSCC) has been reported in north-eastern India and causal association between cancer and raw areca-nut (RAN) consumption are well evident. Earlier studies revealed that monitoring the occurrence… read more here.
Keywords: homozygous genotype; oral cancer; gstp1; genotype gstp1 ... See more keywords