Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2022 at "Journal of basic microbiology"
DOI: 10.1002/jobm.202100622
Abstract: The nucleoside antibiotic toyocamycin (TM), which is produced by Streptomyces diastatochromogenes 1628, exhibits potent activity against a broad range of phytopathogenic fungi. TM was synthesized through a multi-step reaction, using guanosine triphosphate (GTP) as precursor.…
read more here.
Keywords:
precursor;
gtp;
production;
toyocamycin ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.01.016
Abstract: Rac1 is a small member of Rho GTPase family. One of the most important downstream effectors of Rac1 is a serine/threonine kinase, p21-activated kinase 1 (PAK1). Mutational activation of PAK1 by Rac1 has oncogenic signaling…
read more here.
Keywords:
rac1 pak1;
pak1;
gtp;
intrinsic dynamics ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
3
Published in 2022 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2021.105110
Abstract: KRAS mutation is prevalent in around 30% of all cancers and is an undruggable molecular target. Of seven mutations at codon 12 and 13, only one, the G12C mutant is finally proven to be druggable,…
read more here.
Keywords:
silico comparative;
comparative analysis;
gtp;
analysis kras ... See more keywords
Photo from archive.org
Sign Up to like & get
recommendations!
0
Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.02.077
Abstract: Introduction Failures in cognitive and behavioural inhibition are the core of mental disorders, but they are also part of everyday life. Research on Game Transfer Phenomena (GTP) has shown that images, sounds and thoughts from…
read more here.
Keywords:
underlying distressful;
several episodes;
gtp;
factors underlying ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116958
Abstract: AIM To work on Hepatitis C Virus (HCV), one of the major causes of liver cirrhosis and hepatocellular carcinoma, polymerase of genotype 4a that have no solved structures deposited in the protein data bank (PDB)…
read more here.
Keywords:
molecular dynamics;
gtp;
hcv;
polymerase ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2021 at "Structure"
DOI: 10.1016/j.str.2020.12.015
Abstract: By using 31P NMR, we present evidence that the Rho family GTPase RhoA, similar to Ras GTPases, exists in an equilibrium of conformations when bound to GTP. High-resolution crystal structures of RhoA bound to the…
read more here.
Keywords:
bound rhoa;
gtp bound;
gtp;
inactive conformation ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c05137
Abstract: As key regulators of the actin cytoskeleton, RHO GTPase expression and/or activity are deregulated in tumorigenesis and metastatic progression. Nevertheless, the vast majority of experiments supporting this conclusion was conducted on cell lines but not…
read more here.
Keywords:
tumor samples;
breast;
gtp bound;
gtp ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c01470
Abstract: Mutations yield significant effect on the structural flexibility of two switch domains, SW1 and SW2, in K-Ras, which is considered as an important target of anticancer drug design. To unveil a molecular mechanism with regard…
read more here.
Keywords:
sw1 sw2;
gaussian accelerated;
gtp;
gdp gtp ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
2
Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c06926
Abstract: Microtubules (MTs) are essential cellular machines built from concatenated αβ-tubulin heterodimers. They are responsible for two central and opposite functions from the dynamic point of view: scaffolding (static filaments) and force generation (dynamic MTs). These…
read more here.
Keywords:
understand microtubule;
cap;
gtp;
alternative approaches ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
0
Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26324-6
Abstract: Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than…
read more here.
Keywords:
activity cell;
rac1 activity;
gtp levels;
gtp ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03973-6
Abstract: Simple reversible competitive inhibition of nucleotide binding of GTP to Ras family GTPases has long been recognized as an unlikely approach to manipulating the activity of such proteins for experimental or therapeutic purposes. This is…
read more here.
Keywords:
based covalent;
nucleotide based;
covalent inhibitors;
affinity ... See more keywords