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Published in 2021 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23356
Abstract: Type 2 transglutaminase (TG2) functions as an important cancer cell survival protein in a range of cancers including epidermal squamous cell carcinoma. TG2 exists in open and closed conformations each of which has a distinct…
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Keywords:
protein;
tg2;
conformation;
gtp binding ... See more keywords
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Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01070
Abstract: Human tissue transglutaminase (hTG2) is a multifunctional enzyme. It is primarily known for its calcium-dependent transamidation activity that leads to formation of an isopeptide bond between glutamine and lysine residues found on the surface of…
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Keywords:
human tissue;
targeted covalent;
tissue transglutaminase;
gtp binding ... See more keywords
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Published in 2021 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00708
Abstract: Metastasis is a major obstacle in the therapeutic intervention of melanoma, and several GTP-binding proteins were found to play important roles in regulating cancer metastasis. To assess systematically the regulatory roles of these proteins in…
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Keywords:
melanoma;
binding proteins;
melanoma cells;
metastasis ... See more keywords
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Published in 2021 at "Plant physiology"
DOI: 10.1093/plphys/kiab119
Abstract: The extra-large GTP-binding protein 2, XLG2, is an unconventional Gα subunit of the Arabidopsis (Arabidopsis thaliana) heterotrimeric guanosine-5'-triphosphate (GTP)-binding protein complex with a major role in plant defense. In vitro biochemical analyses and molecular dynamic…
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Keywords:
protein;
xlg2;
gtp binding;
extra large ... See more keywords