Articles with "gtp binding" as a keyword



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Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity.

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Published in 2021 at "Molecular carcinogenesis"

DOI: 10.1002/mc.23356

Abstract: Type 2 transglutaminase (TG2) functions as an important cancer cell survival protein in a range of cancers including epidermal squamous cell carcinoma. TG2 exists in open and closed conformations each of which has a distinct… read more here.

Keywords: protein; tg2; conformation; gtp binding ... See more keywords
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Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase.

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Published in 2017 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.7b01070

Abstract: Human tissue transglutaminase (hTG2) is a multifunctional enzyme. It is primarily known for its calcium-dependent transamidation activity that leads to formation of an isopeptide bond between glutamine and lysine residues found on the surface of… read more here.

Keywords: human tissue; targeted covalent; tissue transglutaminase; gtp binding ... See more keywords
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Targeted Quantitative Profiling of GTP-Binding Proteins Associated with Metastasis of Melanoma Cells.

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Published in 2021 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.1c00708

Abstract: Metastasis is a major obstacle in the therapeutic intervention of melanoma, and several GTP-binding proteins were found to play important roles in regulating cancer metastasis. To assess systematically the regulatory roles of these proteins in… read more here.

Keywords: melanoma; binding proteins; melanoma cells; metastasis ... See more keywords
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GTP binding by Arabidopsis extra-large G protein 2 is not essential for its functions.

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Published in 2021 at "Plant physiology"

DOI: 10.1093/plphys/kiab119

Abstract: The extra-large GTP-binding protein 2, XLG2, is an unconventional Gα subunit of the Arabidopsis (Arabidopsis thaliana) heterotrimeric guanosine-5'-triphosphate (GTP)-binding protein complex with a major role in plant defense. In vitro biochemical analyses and molecular dynamic… read more here.

Keywords: protein; xlg2; gtp binding; extra large ... See more keywords