Subnanometer Mechanics of Microtubule Self-(Dis)Assembly
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2019.11.3231
Abstract: Disclosing the metastable nature of microtubules (MTs), long and hollow tubes formed by αβ-tubulin heterodimers, has been a long-standing problem for cell scientists. MTs are essential for cargo transport and provide mechanical forces in chromosome… read more here.
Keywords: gtp hydrolysis; mechanics microtubule; dis assembly; microtubule self ... See more keywords
Quantitative Measurement of Intrinsic GTP Hydrolysis for Carcinogenic Glutamine 61 Mutants in H-Ras.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00878
Abstract: Mutations of human oncoprotein p21H-Ras (hereafter "Ras") at glutamine 61 are known to slow the rate of guanosine triphosphate (GTP) hydrolysis and transform healthy cells into malignant cells. It has been hypothesized that this glutamine… read more here.
Keywords: gtp hydrolysis; quantitative measurement; active site; hydrolysis ... See more keywords
FtsZ induces membrane deformations via torsional stress upon GTP hydrolysis
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DOI: 10.1038/s41467-021-23387-3
Abstract: FtsZ is a key component in bacterial cell division, being the primary protein of the presumably contractile Z ring. In vivo and in vitro, it shows two distinctive features that could so far, however, not… read more here.
Keywords: gtp hydrolysis; ftsz; torsional stress; membrane deformations ... See more keywords
The role of GTP hydrolysis by EF-G in ribosomal translocation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212502119
Abstract: Significance Using ensemble FRET, we measured the effects of inhibition of GTP hydrolysis on rotational movements of the 30S ribosomal subunit and of the head domain of the 30S subunit during ribosomal translocation. Surprisingly, we… read more here.
Keywords: gtp hydrolysis; hydrolysis; role gtp; ribosomal translocation ... See more keywords