In vitro reconstitution of small GTPase regulation
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14540
Abstract: Small GTPases play essential roles in the organization of eukaryotic cells. In recent years, it has become clear that their intracellular functions result from intricate biochemical networks of the GTPase and their regulators that dynamically… read more here.
Keywords: vitro reconstitution; small gtpase; gtpase; reconstitution small ... See more keywords
Corrigendum: A GAL4‐inducible transgenic tool kit for the in vivo modulation of Rho GTPase activity in zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24509
Abstract: Fig. 1. Overview of transgenic constructs. A: Myc-tagged Cdc42 and RhoA constructs are placed downstream of mCherry and the self-cleaving viral peptide f2a, enabling their bicistronic expression following activation of the 10xuas promoter. 10xuas activation… read more here.
Keywords: corrigendum gal4; rho gtpase; inducible transgenic; gal4 inducible ... See more keywords
Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases
Sign Up to like & getrecommendations! Published in 2021 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1678
Abstract: Microexons are small sized (≤51 bp) exons which undergo extensive alternative splicing in neurons, microglia, embryonic stem cells, and cancer cells, giving rise to cell type specific protein isoforms. Due to their small sizes, microexons provide… read more here.
Keywords: microexon alternative; gtpase; central nervous; alternative splicing ... See more keywords
In Vitro Analysis of Tem1 GTPase Activity and Regulation by the Bfa1/Bub2 GAP.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6502-1_6
Abstract: Tem1 is a small GTPase that controls the mitotic progression of Saccharomyces cerevisiae through the Mitotic Exit Network. Tem1 activity is tightly controlled in mitosis by Bub2 and Bfa1 and is also regulated by the… read more here.
Keywords: bub2; bfa1 bub2; vitro analysis; gtpase ... See more keywords
Exploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-021-17059-4
Abstract: The RhoA gene showed an important genotypic association with nicotine dependence and smoking initiation. The current study aims to investigate the effect of the Rho GTPase inhibitor ML141 in the progression of nicotine dependence in… read more here.
Keywords: rho gtpase; nicotine dependence; gtpase; withdrawal syndrome ... See more keywords
Deletion analyses reveal insights into the domain specific activities of an essential GTPase CgtA in Vibrio cholerae.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.03.007
Abstract: CgtA is an essential bacterial GTPase protein involved in multiple cellular activities. In the presence of 50S ribosome, its GTPase activity increases significantly. Through sequential deletions of CgtA protein of Vibrio cholerae (CgtAvc) we found… read more here.
Keywords: vibrio cholerae; gtpase; obg domain;
Extensive GTPase crosstalk regulates Golgi trafficking and maturation.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.01.014
Abstract: Virtually all transport events at the Golgi complex are regulated by Arf and Rab family GTPases. Recent work has advanced our knowledge regarding the mechanisms controlling GTPase activity, and it has become clear that GTPases… read more here.
Keywords: extensive gtpase; crosstalk regulates; gtpase crosstalk; regulates golgi ... See more keywords
Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.02.006
Abstract: Ran is a small ras-related GTPase and is highly expressed in aggressive breast carcinoma. Overexpression induces malignant transformation and drives metastatic growth. We have designed a novel series of anti-Ran-GTPase peptides, which prevents Ran hydrolysis… read more here.
Keywords: peptide; breast; ran gtpase; gtpase ... See more keywords
[A new pathophysiological element in severe asthma: GTPase Rac].
Sign Up to like & getrecommendations! Published in 2022 at "Revue des maladies respiratoires"
DOI: 10.1016/j.rmr.2022.01.009
Abstract: Asthma is a chronic airway condition defined by hyperresponsiveness, bronchial remodeling and chronic inflammation. A significant proportion of severe asthmatic patients remain uncontrolled despite recent therapeutic breakthroughs (biotherapies). Better understanding of the signaling pathways involved… read more here.
Keywords: element severe; severe asthma; asthma gtpase; new pathophysiological ... See more keywords
Designing Single-Component Optogenetic Membrane Recruitment Systems: The Rho-Family GTPase Signaling Toolbox.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00604
Abstract: We describe the efficient creation of single-component optogenetic tools for membrane recruitment-based signaling perturbation using BcLOV4 technology. The workflow requires two plasmids to create six different domain arrangements of the dynamic membrane binder BcLOV4, a… read more here.
Keywords: gtpase; family gtpase; single component; rho family ... See more keywords
Regulation of the small GTPase Rab1 function by a bacterial glucosyltransferase
Sign Up to like & getrecommendations! Published in 2018 at "Cell Discovery"
DOI: 10.1038/s41421-018-0055-9
Abstract: Posttranslational modification of key host proteins by virulence factors is an important theme in bacterial pathogenesis. A remarkable example is the reversible modifications of the small GTPase Rab1 by multiple effectors of the bacterial pathogen… read more here.
Keywords: glucosyltransferase; rab1; small gtpase; gtpase ... See more keywords