Pan-neuronal knockdown of Ras GTPase-activating protein 1 alters Drosophila activity and sleep behavior.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.22001
Abstract: Ras signaling pathways are involved in numerous cellular functions and, for this reason, are highly regulated. In addition to alterations in the Ras proteins themselves, defects in Ras regulatory proteins, such as GTPase-activating proteins (GAPs)… read more here.
Keywords: behavior; gtpase activating; physiology; activity ... See more keywords
Solution structure and dynamics of the mitochondrial‐targeted GTPase‐activating protein (GAP) VopE by an integrated NMR/SAXS approach
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4282
Abstract: The bacterial pathogen Vibrio cholerae use a type III secretion system to inject effector proteins into a host cell. Recently, a putative Toxic GTPase Activating Protein (ToxGAP) called Vibrio outer protein E (VopE) was identified… read more here.
Keywords: structure; gtpase activating; vope; activating protein ... See more keywords
The role of GTPase-activating protein ARHGAP26 in human cancers.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04274-3
Abstract: Rho GTPases are molecular switches that play an important role in regulating the behavior of a variety of tumor cells. RhoA GTPase-activating protein 26 (ARHGAP26) is a GTPase-activating protein and inhibits the activity of Rho… read more here.
Keywords: role; protein arhgap26; gtpase activating; activating protein ... See more keywords
GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12544-4
Abstract: Immunotherapy involving checkpoint blockades of inhibitory co-receptors is effective in combating cancer. Despite this, the full range of mediators that inhibit T-cell activation and influence anti-tumor immunity is unclear. Here, we identify the GTPase-activating protein… read more here.
Keywords: tumor immunity; gtpase activating; activating protein; cell ... See more keywords
Fine-tuning the orientation of the polarity axis by Rga1, a Cdc42 GTPase-activating protein
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-01-0074
Abstract: In vivo and in vitro analyses reveal how a Cdc42 GTPase-activating protein (GAP) interacts with other negative polarity cues at old division sites in budding yeast. Mathematical modeling suggests that spatial distribution of a Cdc42… read more here.
Keywords: cdc42 gtpase; fine tuning; gtpase activating; tuning orientation ... See more keywords
IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s.
Sign Up to like & getrecommendations! Published in 2019 at "International immunology"
DOI: 10.1093/intimm/dxz077
Abstract: Group 2 innate lymphoid cells (ILC2s) play critical roles in type 2 immunity and are crucial for pathogenesis of various types of inflammatory disease. IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a ubiquitously expressed scaffold… read more here.
Keywords: lung ilc2s; containing gtpase; gtpase activating; ilc2s ... See more keywords
Effects of the Rho GTPase‐activating toxin CNF1 on fibroblasts derived from Rett syndrome patients: A pilot study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17624
Abstract: The bacterial product CNF1, through its action on the Rho GTPases, is emerging as a modulator of crucial signalling pathways involved in selected neurological diseases characterized by mitochondrial dysfunctions. Mitochondrial impairment has been hypothesized to… read more here.
Keywords: rho gtpase; gtpase activating; rett syndrome; rtt fibroblasts ... See more keywords
IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway
Sign Up to like & getrecommendations! Published in 2017 at "Tumor Biology"
DOI: 10.1177/1010428317705769
Abstract: IQ-domain GTPase-activating protein 1 is a scaffolding protein with multidomain which plays a role in modulating dishevelled (Dvl) nuclear translocation in canonical Wnt pathway. However, the biological function and mechanism of IQ-domain GTPase-activating protein 1… read more here.
Keywords: invasive ductal; gtpase activating; activating protein; domain gtpase ... See more keywords
Ras GTPase-activating proteins control neuronal circuit development in barrel cortex layer 4
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.901774
Abstract: The cerebral cortex comprises a complex and exquisite network of neuronal circuits that is formed during development. To explore the molecular mechanisms involved in cortical circuit formation, the tactile somatosensory pathway that connects the whiskers… read more here.
Keywords: ras gtpase; activating proteins; circuit; gtpase activating ... See more keywords
Role of IQ Motif-Containing GTPase-Activating Proteins in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.920652
Abstract: IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins, including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by facilitating cytoskeletal remodeling and cellular signal transduction. The role of IQGAPs in cancer… read more here.
Keywords: hepatocellular carcinoma; activating proteins; role; motif containing ... See more keywords
Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.58857
Abstract: Rac GTPase activating protein 1 (RACGAP1) has been characterized in the pathogenesis and progression of several malignancies, however, little is known regarding its role in the development of gallbladder cancer (GBC). This investigation seeks to… read more here.
Keywords: racgap1; apoptosis; gtpase activating; rac gtpase ... See more keywords