The Rho GTPase signalling pathway in urothelial carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Urology"
DOI: 10.1038/nrurol.2017.184
Abstract: Urothelial carcinoma remains a clinical challenge: non-muscle-invasive disease has a high rate of recurrence and risk of progression, and outcomes for patients with advanced disease are poor, owing to a lack of effective systemic therapies.… read more here.
Keywords: carcinoma; rho gtpase; gtpase signalling; signalling pathway ... See more keywords
RAS GTPase signalling to alternative effector pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society transactions"
DOI: 10.1042/bst20200506
Abstract: RAS GTPases are fundamental regulators of development and drivers of an extraordinary number of human cancers. RAS oncoproteins constitutively signal through downstream effector proteins, triggering cancer initiation, progression and metastasis. In the absence of targeted… read more here.
Keywords: alternative effector; signalling alternative; gtpase signalling; gtpase ... See more keywords