Effect of guanidine and arginine on protein–ligand interactions in multimodal cation‐exchange chromatography
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2419
Abstract: The addition of fluid phase modifiers provides significant opportunities for increasing the selectivity of multimodal chromatography. In order to optimize this selectivity, it is important to understand the fundamental interactions between proteins and these modifiers.… read more here.
Keywords: guanidine; guanidine arginine; effect guanidine; chromatography ... See more keywords
New guanidine-containing polyelectrolytes as advanced antibacterial materials
Sign Up to like & getrecommendations! Published in 2018 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2018.06.014
Abstract: Abstract New copolymer of 2,2-diallyl-1,1,3,3-tetraethylguanidiniumchloride and 2-hydroxyethylacrylate was obtained by free radical copolymerization technique for the first time. It was found that 2,2-diallyl-1,1,3,3-tetraethylguanidinium chloride is involved in copolymerization with acrylate to give rise to pyrrolidinium… read more here.
Keywords: advanced antibacterial; containing polyelectrolytes; guanidine; polyelectrolytes advanced ... See more keywords
Metabolism of Free Guanidine in Bacteria Is Regulated by a Widespread Riboswitch Class.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2016.11.019
Abstract: The guanidyl moiety is a component of fundamental metabolites, including the amino acid arginine, the energy carrier creatine, and the nucleobase guanine. Curiously, reports regarding the importance of free guanidine in biology are sparse, and… read more here.
Keywords: guanidine; bacteria regulated; guanidine bacteria; metabolism free ... See more keywords
Optimizing the Bacteriostatic and Cytocompatibility Properties of Poly(hexamethylene guanidine) Hydrochloride (PHMG) via the Guanidine/Alkane Ratio.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00233
Abstract: The emergence of "superbugs" is not only problematic and potentially lethal for infected subjects but also poses serious challenges for the healthcare system. Although existing antibacterial agents have been effective in some cases, the side… read more here.
Keywords: hydrochloride phmg; guanidine hydrochloride; ratio; hexamethylene guanidine ... See more keywords
Novel Pyridazin-3(2H)-one-Based Guanidine Derivatives as Potential DNA Minor Groove Binders with Anticancer Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.1c00633
Abstract: Novel aryl guanidinium analogues containing the pyridazin-3(2H)-one core were proposed as minor groove binders (MGBs) with the support of molecular docking studies. The target dicationic or monocationic compounds, which show the guanidium group at different… read more here.
Keywords: one based; guanidine; pyridazin one; minor groove ... See more keywords
Palladium Nanoparticle-Decorated Porous Metal–Organic-Framework (Zr)@Guanidine: Novel Efficient Catalyst in Cross-Coupling (Suzuki, Heck, and Sonogashira) Reactions and Carbonylative Sonogashira under Mild Conditions
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c01179
Abstract: A novel heterogeneous Zr-based metal–organic framework containing an amino group functionalized with nitrogen-rich organic ligand (guanidine), through a step-by-step post synthesis modification approach, was successfully modified by the stabilization of palladium metal nanoparticles on the… read more here.
Keywords: catalyst; organic framework; guanidine; microscopy ... See more keywords
Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2118400
Abstract: Abstract Isopropoxy benzene guanidine (IBG) is a novel substituted benzene guanidine analogue with antibacterial activity against multidrug-resistant bacteria. However, the bioavailability of IBG is not optimal due to its finite aqueous solubility, thus hampering its… read more here.
Keywords: isopropoxy benzene; guanidine; bioavailability; benzene guanidine ... See more keywords
A variant of guanidine-IV riboswitches exhibits evidence of a distinct ligand specificity
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2022.2160562
Abstract: ABSTRACT Riboswitches are regulatory RNAs that specifically bind a small molecule or ion. Like metabolite-binding proteins, riboswitches can evolve new ligand specificities, and some examples of this phenomenon have been validated. As part of work… read more here.
Keywords: guanidine; gd4v motif; ligand; riboswitch ... See more keywords
Structural basis for guanidine sensing by the ykkC family of riboswitches.
Sign Up to like & getrecommendations! Published in 2017 at "RNA"
DOI: 10.1261/rna.060186.116
Abstract: Regulation of gene expression by cis-encoded riboswitches is a prevalent theme in bacteria. Of the hundreds of riboswitch families identified, the majority of them remain as orphans, without a clear ligand assignment. The ykkC orphan… read more here.
Keywords: structural basis; sensing ykkc; guanidine; family ... See more keywords
Investigation of the proton relay system operative in human cystosolic aminopeptidase P
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0190816
Abstract: Aminopeptidase P, a metalloprotease, targets Xaa-Proline peptides for cleavage [1–4]. There are two forms of human AMPP, a membrane-bound form (hmAMPP) and a soluble cytosolic form (hcAMPP)[5]. Similar to the angiotensin-I-converting enzyme, AMPP plays an… read more here.
Keywords: relay system; guanidine; aminopeptidase; hcampp ... See more keywords
Hypoglycemic potential of cyclic guanidine derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Pure and Applied Chemistry"
DOI: 10.1515/pac-2016-1024
Abstract: Abstract Guanidine derivatives are widely used antidiabetic drugs. Metformin (biguanide) is the first-line therapy for the type 2 diabetes mellitus due to its multi-target and pleiotropic effects. Compounds that comprise guanidine moiety integrated in a… read more here.
Keywords: guanidine derivatives; guanidine; chemistry; potential cyclic ... See more keywords