Hypoxanthine‐guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14306
Abstract: Hypoxanthine‐guanine phosphoribosyltransferase (HGPRT) is a key enzyme in the purine salvage pathway. Here, the reverse reaction of HGPRT from the thermophilic bacterium Hungateiclostridium thermocellum was studied in the presence of IMP and pyrophosphate. As for the… read more here.
Keywords: phosphoribosyltransferase activated; hypoxanthine guanine; guanine phosphoribosyltransferase; imp ... See more keywords
Spin‐projected QM/MM Free Energy Simulations for Oxidation Reaction of Guanine in B−DNA by Singlet Oxygen
Sign Up to like & getrecommendations! Published in 2021 at "Chemphyschem"
DOI: 10.1002/cphc.202000978
Abstract: Abstract Guanine is the most susceptible base to oxidation damage induced by reactive oxygen species including singlet oxygen (1O2, 1Δg). We clarify whether the first step of guanine oxidation in B−DNA proceeds via either a… read more here.
Keywords: oxygen; guanine; energy; spin ... See more keywords
A DFT investigation on interactions between asymmetric derivatives of cisplatin and nucleobase guanine
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2017.05.028
Abstract: Abstract The interactions of hydrolysis products of cisplatin and its asymmetric derivatives cis - and trans -[PtCl 2 ( i Pram)(Mepz)] with guanine were studied using DFT methods. These interactions are dominated by electrostatic effects,… read more here.
Keywords: guanine; investigation interactions; hydrogen bond; interactions asymmetric ... See more keywords
Anhydrous β-guanine crystals in a marine dinoflagellate: Structure and suggested function.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2019.04.009
Abstract: Guanine crystals are used by certain animals, including vertebrates, to produce structural colors or to enhance vision, because of their distinctive reflective properties. Here we use cryo-SEM, cryo- FIB SEM and Raman spectroscopic imaging to… read more here.
Keywords: marine dinoflagellate; guanine; anhydrous guanine; guanine crystals ... See more keywords
Electrochemical sensing and simultaneous determination of guanine and adenine based on covalent organic frameworks/NH2-rG/MoS2 modified glassy carbon electrode
Sign Up to like & getrecommendations! Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2020.105759
Abstract: Abstract Alteration in the concentration of guanine (G) and adenine (A) leads to various abnormalities in the metabolic process which causes various diseases. Therefore, it is still remains a challenge to establish an accurate, simple… read more here.
Keywords: glassy carbon; guanine; organic frameworks; guanine adenine ... See more keywords
Sonochemical-solvothermal synthesis of guanine embedded copper based metal-organic framework (MOF) and its effect on oprD gene expression in clinical and standard strains of Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2018 at "Ultrasonics sonochemistry"
DOI: 10.1016/j.ultsonch.2017.11.035
Abstract: The guanine incropped Cu based metal-organic framework (Guanine-Cu-MOF) was synthesized by facile one-step sonochemical method by simply mixing of 4-4, biphenyldicarboxylic, guanine and copper nitrate (Bio-Cu-H2bpdc-Gu). The prepared guanine-MOF was characterized by using X-Ray diffraction… read more here.
Keywords: oprd gene; guanine; mof; gene expression ... See more keywords
Computational Study of the Oxidation of Guanine to Form 5-Carboxyamido-5-formamido-2-iminohydantoin (2Ih).
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00304
Abstract: Oxidative damage to DNA leads to a number of two-electron oxidation products of guanine such as 8-oxo-7,8-dihydroguanine (8oxoG). 5-carboxyamido-5-formamido-2-iminohydantoin (2Ih) is another two-electron oxidation product that forms in competition with 8oxoG. The pathways for the… read more here.
Keywords: guanine; oxidation; addition; carboxyamido formamido ... See more keywords
Tandem lesions arising from 5-(uracilyl)methyl peroxyl radical addition to guanine: Product analysis and mechanistic studies.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00407
Abstract: The reaction of hydroxyl radical (HO●) with thymine in DNA generates 5-(uracilyl)-methyl radicals (T●) and the corresponding methylperoxyl radical (TOO●) in the presence of O2, which in turn propagates damage by reacting with a vicinal… read more here.
Keywords: tandem lesions; guanine; uracilyl methyl; addition guanine ... See more keywords
Repurposing the Damage Repair Protein Methyl Guanine Methyl Transferase as a Ligand Inducible Fusion Degron.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00771
Abstract: We successfully repurpose the DNA repair protein methylguanine methyltransferase (MGMT) as an inducible degron for protein fusions. MGMT is a suicide protein that removes alkyl groups from the O6 position of guanine (O6G) and is… read more here.
Keywords: fusion; degron; repurposing damage; guanine ... See more keywords
Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00368
Abstract: In tRNAAsp, tRNAAsn, tRNATyr, and tRNAHis of most bacteria and eukaryotes, the anticodon wobble position may be occupied by the modified nucleoside queuosine, which affects the speed and the accuracy of translation. Since eukaryotes are… read more here.
Keywords: trna guanine; tgt; murine; guanine transglycosylase ... See more keywords
Selective Targeting of Guanine-Vacancy-Bearing G-Quadruplexes by G-Quartet Complementation and Stabilization with a Guanine-Peptide Conjugate.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c00774
Abstract: Stabilization of G-quadruplexes (G4s) formed in guanine-rich (G-rich) nucleic acids by small-molecule ligands has been extensively explored as a therapeutic approach for diseases such as cancer. Finding ligands with sufficient affinity and specificity towards G4s… read more here.
Keywords: guanine; stabilization; bearing quadruplexes; vacancy bearing ... See more keywords