The guanine nucleotide exchange factor Vav3 modulates oligodendrocyte precursor differentiation and supports remyelination in white matter lesions
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23548
Abstract: The tightly controlled processes of myelination and remyelination require the participation of the cytoskeleton. The reorganization of the cytoskeleton is controlled by small GTPases of the RhoA family. Here, we report that Vav3, a Rho… read more here.
Keywords: guanine nucleotide; nucleotide exchange; remyelination; exchange factor ... See more keywords
Phenotype and genotype spectrum of variants in guanine nucleotide exchange factor genes in a broad cohort of Iranian patients
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1894
Abstract: Guanine nucleotide exchange factors (GEFs) play pivotal roles in neuronal cell functions by exchanging GDP to GTP nucleotide and activation of GTPases. We aimed to determine the genotype and phenotype spectrum of GEF mutations by… read more here.
Keywords: phenotype genotype; nucleotide exchange; guanine nucleotide; spectrum ... See more keywords
Mechanistic insights on cytotoxicity of KOLR, Cinnamomum pauciflorum Nees leaf derived active ingredient, by targeting signaling complexes of phosphodiesterase 3B and rap guanine nucleotide exchange factor 3
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7521
Abstract: Protein signaling complexes play important roles in prevention of several cancer types and can be used for development of targeted therapy. The roles of signaling complexes of phosphodiesterase 3B (PDE3B) and Rap guanine nucleotide exchange… read more here.
Keywords: complexes phosphodiesterase; rap guanine; nucleotide exchange; guanine nucleotide ... See more keywords
Ras-Guanine Nucleotide Complexes: A UV Spectral Deconvolution Method to Analyze Protein Concentration, Nucleotide Stoichiometry, and Purity.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.114066
Abstract: The many members of the Ras superfamily are small GTPases that serve as molecular switches. These proteins bind the guanine nucleotides GTP and GDP with picomolar affinities, thereby stabilizing on- and off-signaling states, respectively. Quantitative… read more here.
Keywords: protein; guanine nucleotide; deconvolution method; spectral deconvolution ... See more keywords
Expression and localization of guanine nucleotide-binding protein alpha S in the testis and epididymis of rams at different developmental stages.
Sign Up to like & getrecommendations! Published in 2017 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2017.01.006
Abstract: The guanine nucleotide-binding alpha S subunit (Gαs) is an important element of key signaling pathways, which is widely expressed in mammalian tissues; however, its role in the reproductive system is still unclear. In this study,… read more here.
Keywords: different developmental; guanine nucleotide; rams different; nucleotide binding ... See more keywords
WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.090
Abstract: Regulated inter-mitochondrial fusion/fission is essential for maintaining optimal mitochondrial respiration and control of apoptosis and autophagy. In mammals, mitochondrial fusion is controlled by outer membrane GTPases MFN1 and MFN2 and by inner membrane (IM) GTPase… read more here.
Keywords: important mitochondrial; nucleotide exchange; guanine nucleotide; exchange factor ... See more keywords
Loss of Arf Guanine Nucleotide Exchange Factor GBF1 Activity Disturbs Organelle Dynamics in Mouse Oocytes
Sign Up to like & getrecommendations! Published in 2021 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927620024885
Abstract: Abstract GBF1 [Golgi brefeldin A (BFA) resistance factor 1] is a member of the guanine nucleotide exchange factors Arf family. GBF1 localizes at the cis-Golgi and endoplasmic reticulum (ER)-Golgi intermediate compartment where it participates in… read more here.
Keywords: gbf1 activity; organelle dynamics; gbf1; nucleotide exchange ... See more keywords
Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00706
Abstract: Arf GTPases and their guanine nucleotide exchange factors (ArfGEFs) are major regulators of membrane traffic and organelle structure in cells. They are associated with a variety of diseases and are thus attractive therapeutic targets for… read more here.
Keywords: guanine nucleotide; nucleotide exchange; family wide; exchange factors ... See more keywords
Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b13703
Abstract: Small GTPases (sGTPases) are critical switch-like regulators that mediate several important cellular functions and are often mutated in human cancers. They are activated by guanine nucleotide exchange factors (GEFs), which specifically catalyze the exchange of… read more here.
Keywords: guanine nucleotide; nucleotide exchange; real time; time nmr ... See more keywords
A novel missense variant of the GNAI3 gene and recognisable morphological characteristics of the mandibula in ARCND1
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Human Genetics"
DOI: 10.1038/s10038-021-00915-z
Abstract: Auriculocondylar syndrome (ARCND) is an autosomal monogenic disorder characterised by external ear abnormalities and micrognathia due to hypoplasia of the mandibular rami, condyle and coronoid process. Genetically, three subtypes of ARCND (ARCND1, ARCND2 and ARCND3)… read more here.
Keywords: guanine nucleotide; nucleotide binding; gnai3; gnai3 gene ... See more keywords
Sensitive Sequencing Analysis Suggests Thyrotropin Receptor and Guanine Nucleotide-Binding Protein G Subunit Alpha as Sole Driver Mutations in Hot Thyroid Nodules
Sign Up to like & getrecommendations! Published in 2020 at "Thyroid"
DOI: 10.1089/thy.2019.0648
Abstract: Background: Constitutively activating mutations in the thyrotropin receptor (TSHR) and the guanine nucleotide-binding protein G subunit alpha (GNAS) are the primary cause of hot thyroid nodules (HT... read more here.
Keywords: protein subunit; binding protein; thyrotropin receptor; nucleotide binding ... See more keywords