Hypoxanthine‐guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14306
Abstract: Hypoxanthine‐guanine phosphoribosyltransferase (HGPRT) is a key enzyme in the purine salvage pathway. Here, the reverse reaction of HGPRT from the thermophilic bacterium Hungateiclostridium thermocellum was studied in the presence of IMP and pyrophosphate. As for the… read more here.
Keywords: phosphoribosyltransferase activated; hypoxanthine guanine; guanine phosphoribosyltransferase; imp ... See more keywords
Hypoxanthine Guanine Phosphoribosyltransferase expression is negatively correlated with immune activity through its regulation of purine synthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunobiology"
DOI: 10.1016/j.imbio.2020.151931
Abstract: INTRODUCTION The purpose of this study was to examine the effects of elevated Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) on the immune response in the tumor microenvironment. METHODOLOGY HPRT expression was evaluated in cancer patients and correlated… read more here.
Keywords: negatively correlated; guanine phosphoribosyltransferase; expression; cell ... See more keywords