Platinum(II) and palladium(II) complexes of tridentate hydrazone-based ligands as selective guanine quadruplex binders.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.07.003
Abstract: Several tridentate hydrazone-based ligands, synthesized by a condensation reaction of either 2-(1-methylhydrazinyl)pyridine or 2-(1-methylhydrazinyl)quinoline with an aldehyde (picolinaldehyde, 1H-pyrrole-2-carbaldehyde, 2-mercaptobenzaldehyde, 2-aminobenzaldehyde) have been reacted with palladium(II) and platinum(II) salts and precursor complexes to yield nine… read more here.
Keywords: hydrazone based; based ligands; guanine quadruplex; spectroscopy ... See more keywords
Understanding alkali metal cation affinities of multi-layer guanine quadruplex DNA
Sign Up to like & getrecommendations! Published in 2020 at "Physical Chemistry Chemical Physics"
DOI: 10.1039/d0cp03433a
Abstract: To gain better understanding of the stabilizing interactions between metal ions and DNA quadruplexes, dispersion-corrected density functional theory (DFT-D) based calculations were performed on double-, triple- and four-layer guanine tetrads interacting with alkali metal cations.… read more here.
Keywords: dna; alkali metal; guanine quadruplex; layer guanine ... See more keywords
Theoretical insight into the reaction mechanism of hydroxyl radical and guanine in G-quadruplex DNA
Sign Up to like & getrecommendations! Published in 2023 at "Physical Chemistry Chemical Physics"
DOI: 10.1039/d3cp01772a
Abstract: A DFT investigation was performed to illuminate the obscure mechanism of hydroxyl radical (OH˙) and guanine in G-quadruplex by mapping the energy profiles for both addition and hydrogen abstraction reactions. Results revealed that in G-quadruplex,… read more here.
Keywords: mechanism hydroxyl; hydroxyl radical; guanine quadruplex; radical guanine ... See more keywords
Enhancement of the Immunostimulatory Effect of Phosphodiester CpG Oligodeoxynucleotides by an Antiparallel Guanine-Quadruplex Structural Scaffold
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11111617
Abstract: Guanine-quadruplex-based CpG oligodeoxynucleotides (G4 CpG ODNs) have been developed as potent immunostimulatory agents with reduced sensitivity to nucleases. We designed new monomeric G4 ODNs with an antiparallel topology using antiparallel type duplex/G4 ODNs as robust… read more here.
Keywords: topology; cpg odns; guanine quadruplex; cpg oligodeoxynucleotides ... See more keywords
Selection of Olduvai Domains during Evolution: A Role for Primate-Specific Splicing Super-Enhancer and RNA Guanine Quadruplex in Bipartite NBPF Exons
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12070874
Abstract: Olduvai protein domains (also known as DUF1220 or NBPF) have undergone the greatest human-specific increase in the copy number of any coding region in the genome. Their repeat number was strongly associated with the evolutionary… read more here.
Keywords: rna guanine; enhancer; super enhancer; guanine quadruplex ... See more keywords