19F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase.
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DOI: 10.1021/acschembio.2c00080
Abstract: Understanding the structural arrangements of protein oligomers can support the design of ligands that interfere with their function in order to develop new therapeutic concepts for disease treatment. Recent crystallographic studies have elucidated a novel… read more here.
Keywords: inactive twisted; conformation; trna guanine; 19f nmr ... See more keywords
Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.
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DOI: 10.1021/acschembio.2c00368
Abstract: In tRNAAsp, tRNAAsn, tRNATyr, and tRNAHis of most bacteria and eukaryotes, the anticodon wobble position may be occupied by the modified nucleoside queuosine, which affects the speed and the accuracy of translation. Since eukaryotes are… read more here.
Keywords: trna guanine; tgt; murine; guanine transglycosylase ... See more keywords