Guanosine, a guanine-based nucleoside relaxed isolated corpus cavernosum from mice through cGMP accumulation
Sign Up to like & getrecommendations! Published in 2020 at "Purinergic Signalling"
DOI: 10.1007/s11302-020-09702-5
Abstract: In corpus cavernosum (CC), guanosine triphosphate (GTP) is converted into cyclic guanosine monophosphate (cGMP) to induce erection. The action of cGMP is terminated by phosphodiesterases and efflux transporters, which pump cGMP out of the cell.… read more here.
Keywords: guanosine; corpus cavernosum; guanine based; cgmp ... See more keywords
Enhanced solubility of guanosine by inclusion complexes with cyclodextrin derivatives: Preparation, characterization, and evaluation.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115166
Abstract: This study improves the water solubility and cellular uptake of guanosine (GuN) through an inclusion complexation with cyclodextrin derivatives (CDs), namely β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), and sulfobutyl ether-β-cyclodextrin (SBE-β-CD). Inclusion complexes of GuN and CDs… read more here.
Keywords: inclusion complexes; gun; inclusion; solubility ... See more keywords
Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.08.006
Abstract: BACKGROUND Guanosine is a natural product and an endogenous nucleoside that has shown to increase during myocardial ischemia. Platelets are critically involved in ischemic coronary events. It remains unknown, however, whether guanosine may affect platelet… read more here.
Keywords: guanosine; antithrombotic properties; activation; camp pka ... See more keywords
Augmentation effect of ketamine by guanosine in the novelty-suppressed feeding test is dependent on mTOR signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2019.05.017
Abstract: The ketamine's potential for the treatment of refractory depression and anxiety has been considered one the most important discoveries in the last years, however, repeated use of ketamine is limited due to its side/adverse effects.… read more here.
Keywords: guanosine; ketamine; effect; augmentation ... See more keywords
Adenosine, but not guanosine, protects vaginal epithelial cells from Trichomonas vaginalis cytotoxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Microbes and infection"
DOI: 10.1016/j.micinf.2016.11.001
Abstract: Trichomonas vaginalis causes the most common non-viral sexually transmitted disease worldwide. The cytoadherence and cytotoxicity upon the vaginal epithelial cells are crucial for the infection. Extracellular nucleotides are released during cell damage and, along with… read more here.
Keywords: epithelial cells; vaginalis cytotoxicity; vaginal epithelial; guanosine ... See more keywords
A low-dose combination of ketamine and guanosine counteracts corticosterone-induced depressive-like behavior and hippocampal synaptic impairments via mTORC1 signaling
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2021.110371
Abstract: Ketamine exhibits rapid and sustained antidepressant responses, but its repeated use may cause adverse effects. Augmentation strategies have been postulated to be useful for the management/reduction of ketamine's dose and its adverse effects. Based on… read more here.
Keywords: mtorc1 signaling; guanosine; ketamine; depressive like ... See more keywords
Highly regioselective 1,3-dipolar cycloaddition of 3′-O-propargyl guanosine with nitrile oxide: An efficient method for the synthesis of guanosine containing isoxazole moiety
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152464
Abstract: The 1,3-dipolar cycloaddition reaction of 3′-O-propargyl guanosine with various in-situ generated nitrile oxides in the presence of DMF as a solvent is described. It is noteworthy that the reaction is highly regioselective that affords biologically… read more here.
Keywords: guanosine containing; guanosine; propargyl guanosine; containing isoxazole ... See more keywords
Dynamic and Rapid Detection of Guanosine during Ischemia.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00048
Abstract: Guanosine acts in both neuroprotective and neurosignaling pathways in the central nervous system; in this paper, we present the first fast voltammetric measurements of endogenous guanosine release during pre- and post-ischemic conditions. We discuss the… read more here.
Keywords: ischemia; guanosine release; detection guanosine; rapid detection ... See more keywords
On the structural stability of guanosine-based supramolecular hydrogels.
Sign Up to like & getrecommendations! Published in 2018 at "Soft matter"
DOI: 10.1039/c8sm00299a
Abstract: Supramolecular hydrogels formed from the self-assembly of low molecular weight derivatives are very attractive systems, because of their potential applications in nano- and bio-technology. In this paper, the stable and transparent hydrogels observed in binary… read more here.
Keywords: supramolecular hydrogels; guanosine based; guanosine; stability guanosine ... See more keywords
Antiproliferation effect of guanosine on HCT 116 cells involves MAPK and AMPK pathways
Sign Up to like & getrecommendations! Published in 2017 at "Nucleosides, Nucleotides and Nucleic Acids"
DOI: 10.1080/15257770.2016.1268693
Abstract: ABSTRACT This study aims to investigate the mechanisms associated with the antiproliferation effect of guanosine on human colon carcinoma HCT 116 cells. In this study, guanosine induced more drastic cell cycle arrest effect than cell… read more here.
Keywords: 116 cells; hct 116; guanosine; effect guanosine ... See more keywords
Purine Nucleosides Interfere with c-di-AMP Levels and Act as Adjuvants To Re-Sensitize MRSA To β-Lactam Antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02478-22
Abstract: The clinical burden of infections caused by antimicrobial resistant (AMR) pathogens is a leading threat to public health. Maintaining the effectiveness of existing antimicrobial drugs or finding ways to reintroduce drugs to which resistance is… read more here.
Keywords: mrsa lactam; purine nucleosides; lactam resistance; resistance ... See more keywords