Cyclic guanosine monophosphate modulates accumulation of phosphodiesterase 5 inhibitors in human platelets
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.08.026
Abstract: ABSTRACT Sildenafil and tadalafil are widely‐used phosphodiesterase 5 (PDE5) inhibitors for which no clear dose‐response relationship could be established. Using isolated and/or recombinant PDE5, it has been demonstrated that cGMP can increase the affinity of… read more here.
Keywords: guanosine monophosphate; sildenafil tadalafil; tadalafil; pde5 ... See more keywords
Photodissociation spectroscopy of protonated guanosine monophosphate based on IR-laser ablation of droplet beam and quadrupole ion trap mass spectrometry
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Physics Letters"
DOI: 10.1016/j.cplett.2019.02.007
Abstract: Abstract Photodissociation (PD) spectroscopy of protonated guanosine monophosphate (GMPH+) ions was performed using IR-laser ablation of droplet beam and quadruple ion trap techniques. Photofragmentation of GMPH+ gave a protonated guanine ion (GH+) as the main… read more here.
Keywords: guanosine monophosphate; spectroscopy protonated; spectroscopy; ion ... See more keywords
Oxidation potentials of guanine, guanosine and guanosine-5′-monophosphate: Theory and experiment
Sign Up to like & getrecommendations! Published in 2019 at "Electrochimica Acta"
DOI: 10.1016/j.electacta.2019.06.052
Abstract: Abstract Guanine, having lower one-electron oxidation potential than other nucleobases, is of relevance to oxidative degradation of nucleic acids in mutagenesis, carcinogenesis, and aging. Here we compare oxidation potentials of guanine (G), guanosine (Guo), deoxyguanosine… read more here.
Keywords: guanosine monophosphate; oxidation; guanine guanosine; potentials guanine ... See more keywords
Targeting Cyclic Guanosine Monophosphate to Treat Heart Failure: JACC Review Topic of the Week.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2020.08.031
Abstract: The significant morbidity and mortality associated with heart failure with reduced ejection fraction (HFrEF) or heart failure with preserved ejection fraction (HFpEF) justify the search for novel therapeutic agents. Reduced cyclic guanosine monophosphate levels contribute… read more here.
Keywords: guanosine monophosphate; cyclic guanosine; heart; heart failure ... See more keywords
Elevated plasma cyclic guanosine monophosphate may explain greater efferent arteriolar tone in adults with longstanding type 1 diabetes: A brief report.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of diabetes and its complications"
DOI: 10.1016/j.jdiacomp.2019.05.007
Abstract: Cyclic guanosine monophosphate (cGMP) influences intrarenal hemodynamics in animal models, but the relationship between cGMP and renal function in adults with type 1 diabetes (T1D) remains unclear. In this study, plasma cGMP correlated with efferent… read more here.
Keywords: guanosine monophosphate; cyclic guanosine; efferent arteriolar; type diabetes ... See more keywords
Temperature and pressure limits of guanosine monophosphate self-assemblies
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10689-0
Abstract: Guanosine monophosphate, among the nucleotides, has the unique property to self-associate and form nanoscale cylinders consisting of hydrogen-bonded G-quartet disks, which are stacked on top of one another. Such self-assemblies describe not only the basic… read more here.
Keywords: guanosine monophosphate; self; temperature pressure; self assemblies ... See more keywords
Vitamin-guanosine monophosphate conjugates for in vitro transcription priming.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/c9cc09427j
Abstract: Expanding the catalytic repertoire of ribozymes to include vitamin synthesis requires efficient labelling of RNA with the substrate of interest, prior to in vitro selection. For this purpose, we rationally designed and synthesized six GMP-conjugates… read more here.
Keywords: guanosine monophosphate; transcription; vitro transcription; conjugates vitro ... See more keywords
Cyclic guanosine monophosphate and 10-year change in left ventricular mass: the Multi-Ethnic Study of Atherosclerosis (MESA)
Sign Up to like & getrecommendations! Published in 2021 at "Biomarkers"
DOI: 10.1080/1354750x.2021.1893811
Abstract: Abstract Purpose: Cyclic guanosine monophosphate (cGMP) is a second messenger for natriuretic peptide (NP) and nitric oxide pathways; its enhancement a target for heart failure and cardiovascular disease (CVD). We evaluated whether plasma cGMP was… read more here.
Keywords: guanosine monophosphate; change; cgmp; change left ... See more keywords
Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3’,5’-Monophosphate-Dependent Protein Kinase I
Sign Up to like & getrecommendations! Published in 2022 at "Hypertension"
DOI: 10.1161/hypertensionaha.122.18756
Abstract: Background: We previously demonstrated that nitroxyl causes vasodilation, at least in part, by inducing the formation of an intradisulfide bond between C117 and C195 in the high affinity cyclic guanosine monophosphate-binding site of PKGI (cyclic… read more here.
Keywords: guanosine monophosphate; blood pressure; pressure; cyclic guanosine ... See more keywords
Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.637399
Abstract: Innate immune pathways are the first line of cellular defense against pathogen infections ranging from bacteria to Metazoa. These pathways are activated following the recognition of pathogen associated molecular patterns (PAMPs) by membrane and cytosolic… read more here.
Keywords: guanosine monophosphate; cgas; monophosphate adenosine; cyclic guanosine ... See more keywords
The cyclic guanosine monophosphate synthase-stimulator of interferon genes pathway as a potential target for tumor immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1121603
Abstract: Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self-DNA in the cytoplasm. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein… read more here.
Keywords: cyclic guanosine; monophosphate; guanosine monophosphate; interferon genes ... See more keywords