Pharmacological inhibition of guanosine triphosphate cyclohydrolase1 elevates tyrosine phosphorylation of caveolin1 and cellular senescence
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DOI: 10.1016/j.ejphar.2019.01.036
Abstract: &NA; The role of 2,4‐diamino‐6‐hydroxypyrimidine (DAHP), on cellular‐senescence remains unclear as differential effects of DAHP have been reported in cardiovascular and cerebrovascular systems. We investigated the effect of pharmacologically‐induced guanosine‐triphosphate‐cyclohydrolase1 (GTPCH1)‐inhibition, through DAHP, on cellular‐senescence… read more here.
Keywords: guanosine triphosphate; triphosphate cyclohydrolase1; phosphorylation caveolin1; senescence ... See more keywords
Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate–binding region
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DOI: 10.1111/epi.14653
Abstract: To characterize the phenotypic spectrum associated with GNAO1 variants and establish genotype‐protein structure‐phenotype relationships. read more here.
Keywords: guanosine triphosphate; associated gnao1; spectrum neurodevelopmental; disease associated ... See more keywords
Guanosine-5′-triphosphate cyclohydrolase 1 regulated long noncoding RNAs are potential targets for microglial activation in neuropathic pain
Sign Up to like & getrecommendations! Published in 2021 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.290914
Abstract: Several studies have confirmed that microglia are involved in neuropathic pain. Inhibition of guanosine-5′-triphosphate cyclohydrolase 1 (GTPCH1) can reduce the inflammation of microglia. However, the precise mechanism by which GTPCH1 regulates neuropathic pain remains unclear.… read more here.
Keywords: guanosine triphosphate; long noncoding; triphosphate cyclohydrolase; potential targets ... See more keywords