Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.063
Abstract: Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that this activity is shared by GBP2, but not by other members of the… read more here.
Keywords: exert broad; broad antiviral; guanylate binding; envelope ... See more keywords
Mouse guanylate‐binding protein 1 does not mediate antiviral activity against influenza virus in vitro or in vivo
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12627
Abstract: Many interferon (IFN)‐stimulated genes are upregulated within host cells following infection with influenza and other viruses. While the antiviral activity of some IFN‐stimulated genes, such as the IFN‐inducible GTPase myxoma resistance (Mx)1 protein 1, has… read more here.
Keywords: mgbp1; infection; influenza; guanylate binding ... See more keywords
Processing and secretion of guanylate binding protein‐1 depend on inflammatory caspase activity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13116
Abstract: Human guanylate binding protein‐1 (GBP‐1) belongs to the family of large GTPases. The expression of GBP‐1 is inducible by inflammatory cytokines, and the protein is involved in inflammatory processes and host defence against cellular pathogens.… read more here.
Keywords: caspase; guanylate binding; secretion; gbp ... See more keywords
Critical role of guanylate binding protein 5 in tumor immune microenvironment and predictive value of immunotherapy response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.984615
Abstract: Background: The guanylate-binding proteins (GBPs) are the latest potential targets of immunotherapy. However, the role of GBP5 in pan-cancer, including colorectal cancer (CRC), remains unclear. This study aims to explore the effect of GBP5 on… read more here.
Keywords: gbp5; response; guanylate binding; tumor ... See more keywords
Unraveling the Role of Guanylate-Binding Proteins (GBPs) in Breast Cancer: A Comprehensive Literature Review and New Data on Prognosis in Breast Cancer Subtypes
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14112794
Abstract: Simple Summary Interferons are important in normal breast development, but also in the development and progression of breast cancers. Recently, three members of the Guanylate-Binding Protein (GBP) family of interferon-induced GTPases, GBP-1, GBP-2, and GBP-5,… read more here.
Keywords: breast; guanylate binding; breast cancer; gbp ... See more keywords