The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4938-0
Abstract: RationaleAfter stimulation with nitric oxide, soluble guanylate cyclase (sGC) produces cyclic guanosine monophosphate (cGMP), which stimulates an important signalling pathway for long-term potentiation (LTP). By upregulating cGMP, LTP could be stimulated and thereby enhancing memory… read more here.
Keywords: soluble guanylate; guanylate cyclase; biperiden; performance ... See more keywords
Targeting heme-oxidized soluble guanylate cyclase to promote osteoblast function.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.12.004
Abstract: The enzyme soluble guanylate cyclase (sGC) plays an essential part in the nitric oxide (NO) signaling pathway by binding to the prosthetic heme group; thereby catalyzing the synthesis of cyclic guanosine monophosphate (cGMP)-dependent protein kinases.… read more here.
Keywords: osteoblast function; heme oxidized; soluble guanylate; guanylate cyclase ... See more keywords
Stimulation of nitric oxide‐sensitive soluble guanylate cyclase in monocrotaline‐induced pulmonary hypertensive rats
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.04.045
Abstract: Aims: In this study, we examined whether a disruption in the balance between nitric oxide (NO)‐sensitive and ‐insensitive soluble guanylate cyclase (sGC) is observed in pulmonary hypertension (PH) and whether treatment with NO‐enhancing drugs can… read more here.
Keywords: nitric oxide; soluble guanylate; oxide sensitive; guanylate cyclase ... See more keywords
Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.08.020
Abstract: Endothelial dysfunction is associated with decreased NO bioavailability and impaired activation of the NO receptor soluble guanylate cyclase (sGC) in the vasculature and in platelets. Red blood cells (RBCs) are known to produce NO under… read more here.
Keywords: soluble guanylate; guanylate cyclase; signaling pathway; sgc ... See more keywords
Role of the Coiled-Coil Domain in Allosteric Activity Regulation in Soluble Guanylate Cyclase.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00052
Abstract: Soluble guanylate cyclase (sGC) is the primary nitric oxide (NO) receptor in higher eukaryotes, including humans. NO-dependent signaling via sGC is associated with important physiological effects in the vascular, pulmonary, and neurological systems, and sGC… read more here.
Keywords: soluble guanylate; coiled coil; guanylate cyclase; sgc ... See more keywords
Characterization of a Carbon Monoxide-Activated Soluble Guanylate Cyclase from Chlamydomonas reinhardtii.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00190
Abstract: Signaling pathways that involve diatomic gases in photosynthetic organisms are not well understood. Exposure to nitric oxide or carbon monoxide is known to elicit certain responses in some photosynthetic organisms. For example, Chlamydomonas reinhardtii grown… read more here.
Keywords: cyg11; carbon; soluble guanylate; guanylate cyclase ... See more keywords
Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c02154
Abstract: Herein we describe the discovery, mode of action, and preclinical characterization of the soluble guanylate cyclase (sGC) activator runcaciguat. The sGC enzyme, via the formation of cyclic guanosine monophoshphate, is a key regulator of body… read more here.
Keywords: soluble guanylate; guanylate cyclase; sgc; activator runcaciguat ... See more keywords
New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02082
Abstract: Herein, we describe the identification, chemical optimization, and preclinical characterization of novel soluble guanylate cyclase (sGC) stimulators. Given the very broad therapeutic opportunities for sGC stimulators, new tailored molecules for distinct indications with specific pharmacokinetics,… read more here.
Keywords: sgc stimulators; guanylate cyclase; hypertension; bay 747 ... See more keywords
Molecular determinants of Guanylate Cyclase Activating Protein subcellular distribution in photoreceptor cells of the retina
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20893-1
Abstract: Retinal guanylate cyclase (RetGC) and guanylate cyclase activating proteins (GCAPs) play an important role during the light response in photoreceptor cells. Mutations in these proteins are linked to distinct forms of blindness. RetGC and GCAPs… read more here.
Keywords: cyclase activating; photoreceptor cells; guanylate cyclase; retgc ... See more keywords
The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-021-02275-z
Abstract: Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating neuroinflammation. CYR119 is a CNS-penetrant sGC stimulator… read more here.
Keywords: soluble guanylate; nervous system; central nervous; guanylate cyclase ... See more keywords
Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0190628
Abstract: Objective Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide–cyclic guanosine 3′,5′-monophosphate (NO–cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development of emphysema and pulmonary vascular remodeling… read more here.
Keywords: chronic obstructive; stimulation; soluble guanylate; guanylate cyclase ... See more keywords