Soluble Guanylyl Cyclase Alpha1 Subunit: A New Marker for Estrogenicity of Endocrine Disruptor Compounds.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4591
Abstract: Endocrine disruptor compounds (EDCs) comprise naturally occurring and synthetic substances widely spread in the environment that adversely affect human and wildlife. Because of the increasing number of EDCs, screening methods and ideal biomarkers to determine… read more here.
Keywords: soluble guanylyl; disruptor compounds; guanylyl cyclase; endocrine disruptor ... See more keywords
Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease‐related mutations
Sign Up to like & getrecommendations! Published in 2020 at "IUBMB Life"
DOI: 10.1002/iub.2283
Abstract: Guanylyl cyclase C (GC‐C) is the receptor for the heat‐stable enterotoxin, which causes diarrhea, and the endogenous ligands, guanylin and uroguanylin. GC‐C is predominantly expressed in the intestinal epithelium and regulates fluid and ion secretion… read more here.
Keywords: mutational landscape; analysis; landscape receptor; guanylyl cyclase ... See more keywords
A guanylyl cyclase-thioredoxin transnitrosation complex
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.030
Abstract: Nitric Oxide (NO) is best known for its ability to stimulate soluble guanylyl cyclase (sGC) to produce cGMP and stimulate its downstream signaling pathways. However, NO can also covalently modify cysteines via S-nitrosation (addition of… read more here.
Keywords: protein; transnitrosation; thioredoxin; guanylyl cyclase ... See more keywords
Thermal shift assay: Strengths and weaknesses of the method to investigate the ligand-induced thermostabilization of soluble guanylyl cyclase.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.113065
Abstract: Thermal shift assay is a fluorescence dye based biochemical method to determine the melting point of a protein. It can be used to investigate the ligand-induced stabilization of proteins and helps to increase the likelihood… read more here.
Keywords: shift; shift assay; ligand induced; soluble guanylyl ... See more keywords
C53: A novel particulate guanylyl cyclase B receptor activator that has sustained activity in vivo with anti-fibrotic actions in human cardiac and renal fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.03.024
Abstract: The native particulate guanylyl cyclase B receptor (pGC-B) activator, C-type natriuretic peptide (CNP), induces anti-remodeling actions in the heart and kidney through the generation of the second messenger 3', 5' cyclic guanosine monophosphate (cGMP). Indeed… read more here.
Keywords: anti fibrotic; activator; guanylyl cyclase; particulate guanylyl ... See more keywords
Guanylyl Cyclase A in Both Renal Proximal Tubular and Vascular Endothelial Cells Protects the Kidney against Acute Injury in Rodent Experimental Endotoxemia Models
Sign Up to like & getrecommendations! Published in 2018 at "Anesthesiology"
DOI: 10.1097/aln.0000000000002214
Abstract: What We Already Know about This TopicThe physiologic role of natriuretic peptides is increasingly understood in critical illness, but how these peptides might impact sepsis-induced oliguria is not known What This Article Tells Us That… read more here.
Keywords: glomerular filtration; endothelial cells; rate; guanylyl cyclase ... See more keywords
Nitric oxide‐soluble guanylyl cyclase pathway as a contributor to age‐related memory impairment in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13691
Abstract: Age‐related changes in the transcriptome lead to memory impairment. Several genes have been identified to cause age‐dependent memory impairment (AMI) by changes in their expression, but genetic screens to identify genes critical for AMI have… read more here.
Keywords: memory; guanylyl cyclase; age related; memory impairment ... See more keywords
Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16087
Abstract: BACKGROUND AND PURPOSE Alcohol abuse has been associated with erectile dysfunction (ED) but the molecular mechanisms implicated are unknown. This study analyses the role of alterations in soluble guanylyl cyclase (sGC) in ED. EXPERIMENTAL APPROACH… read more here.
Keywords: soluble guanylyl; guanylyl cyclase; erectile dysfunction; sgc ... See more keywords
Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1111/gbb.12573
Abstract: Guanylyl cyclase C (GC‐C) is found in brain regions where dopamine is expressed. We characterized a mouse in which GC‐C was knocked out (KO) that was reported to be a model of attention deficit hyperactivity… read more here.
Keywords: mouse knockout; recognition; knockout guanylyl; cyclase ... See more keywords
DNA methylation inhibitor regulates guanylyl cyclase/natriuretic peptide receptor-A gene expression via 5'-untranslated region in mesangial and smooth muscle cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731269
Abstract: Guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) is activated by cardiac hormones atrial and brain natriuretic peptides (ANP, BNP) and produces intracellular second messenger cGMP. The physiological actions of ANP/NPRA/cGMP signaling cascade largely include diuresis, natriuresis, vasorelaxation,… read more here.
Keywords: cyclase natriuretic; guanylyl cyclase; region; expression ... See more keywords
Molecular and genetic aspects of guanylyl cyclase natriuretic peptide receptor-A in regulation of blood pressure and renal function.
Sign Up to like & getrecommendations! Published in 2018 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00083.2018
Abstract: Natriuretic peptides (NPs) exert diverse effects on several biological and physiological systems, such as kidney function, neural and endocrine signaling, energy metabolism, and cardiovascular function, playing pivotal roles in the regulation of blood pressure (BP)… read more here.
Keywords: regulation blood; blood pressure; guanylyl cyclase; function ... See more keywords