GUCY2C as a biomarker to target precision therapies for patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Precision Medicine and Drug Development"
DOI: 10.1080/23808993.2021.1876518
Abstract: ABSTRACT Introduction Colorectal cancer (CRC) is one of the most-deadly malignancies worldwide. Current therapeutic regimens for CRC patients are relatively generic, based primarily on disease type and stage, with little variation. As the field of… read more here.
Keywords: medicine; gucy2c; biomarker; colorectal cancer ... See more keywords
739 Development of patient-derived models of esophageal cancer for GUCY2C-directed immunotherapeutic testing
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0739
Abstract: Background Esophageal cancer is the fifth most common cause of cancer-related death in the world1 with a 5-year survival rate of Methods To develop esophageal cancer models for GUCY2C immunotherapy testing, esophageal cancer samples were… read more here.
Keywords: esophageal cancer; gucy2c; jefferson university; thomas jefferson ... See more keywords
GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22084
Abstract: Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes to accommodate normal maintenance and post-injury regeneration of the epithelium. Their long life, lineage plasticity, and proliferative potential underlie the necessity… read more here.
Keywords: gucy2c; stress; gucy2c mice; stem cells ... See more keywords