Practical Guide to Design Choice of Randomized Clinical Trials in Surgery.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA surgery"
DOI: 10.1001/jamasurg.2022.4889
Abstract: This Guide to Statistics and Methods provides an overview of the strengths and weaknesses of several randomized clinical trial design options. read more here.
Keywords: guide; practical guide; randomized clinical; guide design ... See more keywords
Harnessing ecological and evolutionary principles to guide the design of microbial production consortia.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2019.12.012
Abstract: Bacteria are widely used for commercially producing biomolecules. However, attempts to rationally design production strains and optimize cultivation conditions are frequently counteracted by the emergence of mutants with reduced production characteristics that decrease overall process… read more here.
Keywords: ecological evolutionary; evolutionary principles; production; principles guide ... See more keywords
Protein structures guide the design of a much-needed tool for neuroscience
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/d41586-018-06670-0
Abstract: The structures of anion-conducting channelrhodopsin proteins have been solved and used to develop a tool for optogenetics. Experts discuss what the structures tell us about ion conduction, and why the tool is needed.Structures of channelrhodopsins… read more here.
Keywords: protein structures; design much; tool; structures guide ... See more keywords
Improving CRISPR guide design with consensus approaches
Sign Up to like & getrecommendations! Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-6291-z
Abstract: CRISPR-based systems are playing an important role in modern genome engineering. A large number of computational methods have been developed to assist in the identification of suitable guides. However, there is only limited overlap between… read more here.
Keywords: consensus approaches; guide design; improving crispr;
A benchmark of computational CRISPR-Cas9 guide design methods
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007274
Abstract: The popularity of CRISPR-based gene editing has resulted in an abundance of tools to design CRISPR-Cas9 guides. This is also driven by the fact that designing highly specific and efficient guides is a crucial, but… read more here.
Keywords: crispr cas9; guide design; design;