Top-Down Mass Spectrometry of Synthetic Single Guide Ribonucleic Acids Enabled by Facile Sample Clean-Up.
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DOI: 10.1021/acs.analchem.2c03030
Abstract: In recent years, CRISPR-Cas9 genome editing has become an important technology in biomedical research and has demonstrated tremendous therapeutic potential. With Cas9 endonuclease, the use of single guide ribonucleic acids (sgRNAs) allows for sequence-specific cutting… read more here.
Keywords: guide ribonucleic; mass spectrometry; sequence; ribonucleic acids ... See more keywords