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Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00892
Abstract: The Argonaute-2 protein is part of the RNA-induced silencing complex (RISC) and anchors the guide strand of the small interfering RNA (siRNA). The 3'-end of the RNA contains two unpaired nucleotides (3'-overhang) that interact with…
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Keywords:
molecular interaction;
energy profiling;
paz;
guide strand ... See more keywords
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Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00769
Abstract: RNA interference (RNAi) is a well-established research tool and is also maturing as a novel therapeutic approach. For the latter, microRNA-like off-target activity of short interfering RNAs (siRNAs) remains as one of the main problems…
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Keywords:
short interfering;
guide strand;
seed;
target activity ... See more keywords
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Published in 2022 at "Plant biotechnology journal"
DOI: 10.1111/pbi.13786
Abstract: Artificial microRNA (amiRNA) technology has allowed researchers to direct efficient silencing of specific transcripts using as few as 21 nucleotides (nt). However, not all the artificially designed amiRNA constructs result in selection of the intended…
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Keywords:
strand selection;
virus;
strand;
guide strand ... See more keywords