cryoEM‐Guided Development of Antibiotics for Drug‐Resistant Bacteria
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900042
Abstract: While the ribosome is a common target for antibiotics, challenges with crystallography can impede the development of new bioactives using structure‐based drug design approaches. In this study we exploit common structural features present in linezolid‐resistant… read more here.
Keywords: guided development; antibiotics drug; drug; cryoem guided ... See more keywords
Biomarker-Guided Development of DNA Repair Inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.04.035
Abstract: Anti-cancer drugs targeting the DNA damage response (DDR) exploit genetic or functional defects in this pathway through synthetic lethal mechanisms. For example, defects in homologous recombination (HR) repair arise in cancer cells through inherited or… read more here.
Keywords: biomarker guided; guided development; dna repair; repair ... See more keywords
Ab initio-guided development of super-hard Mo–Al–Cr–N coatings
Sign Up to like & getrecommendations! Published in 2017 at "Scripta Materialia"
DOI: 10.1016/j.scriptamat.2017.06.052
Abstract: Abstract The ab initio-guided adjustment in N 2 -partial pressure during reactive magnetron sputtering allowed the preparation of single-phase cubic-structured Mo 1 − x − y Al x Cr y N z coatings with Al-contents up… read more here.
Keywords: initio guided; guided development; hard coatings; super hard ... See more keywords
Structure-guided development of Pb2+-binding DNA aptamers
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-04243-2
Abstract: Owing to its great threat to human health and environment, Pb 2+ pollution has been recognized as a major public problem by the World Health Organization (WHO). Many DNA aptamers have been utilized in the… read more here.
Keywords: development; structure guided; dna aptamers; development pb2 ... See more keywords
TD-DFT-guided development of a robust hole-transporting layer for optimized triple-cation perovskite solar cell performance
Sign Up to like & getrecommendations! Published in 2024 at "New Journal of Chemistry"
DOI: 10.1039/d4nj03550j
Abstract: Perovskite solar cells (PSCs) have earned considerable attention as a promising photovoltaic technology for future power generation. Spiro derivatives are often used as a hole-transporting layer (HTL) in highly efficient... read more here.
Keywords: hole transporting; guided development; transporting layer; dft guided ... See more keywords