In-silico guided discovery of novel CCR9 antagonists
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-018-0113-2
Abstract: Antagonism of CCR9 is a promising mechanism for treatment of inflammatory bowel disease, including ulcerative colitis and Crohn’s disease. There is limited experimental data on CCR9 and its ligands, complicating efforts to identify new small… read more here.
Keywords: novel ccr9; ccr9 antagonists; guided discovery; silico guided ... See more keywords
Computationally Guided Discovery of Axis-Dependent Conduction Polarity in NaSnAs Crystals
Sign Up to like & getrecommendations! Published in 2021 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.0c04030
Abstract: Most electronic materials exhibit a single dominant charge carrier type, either holes or electrons, along all crystallographic directions. However, there are a small number of compounds, mostly met... read more here.
Keywords: computationally guided; dependent conduction; conduction polarity; discovery axis ... See more keywords
Genome Mining and Heterologous Expression-Guided Discovery of Mangicol Sesterterpenoids with Antimicrobial and Antineuroinflammatory Activities.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c04187
Abstract: The accelerating increase in antimicrobial resistance presents serious dangers to global health, food safety, and agricultural productivity. In this study, we explored fungal-derived sesterterpenoids as potential antimicrobial agents, focusing on mangicols biosynthesized by a newly… read more here.
Keywords: guided discovery; genome mining; expression guided; mangicol ... See more keywords
Bioactivity-Guided Discovery of Human Carboxylesterase Inhibitors from the Roots of Paeonia lactiflora.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.0c00464
Abstract: In a continuing search for potential inhibitors against human carboxylesterases 1A1 and 2A1 (hCES1A1 and hCES2A1), an EtOAc extract of the roots of Paeonia lactiflora showed strong hCES inhibition activity. Bioassay-guided fractionation led to the… read more here.
Keywords: bioactivity guided; roots paeonia; guided discovery; discovery human ... See more keywords
Genome-Guided Discovery of the Myxobacterial Thiolactone-Containing Sorangibactins
Sign Up to like & getrecommendations! Published in 2023 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.3c00063
Abstract: In this study, an unprecedented myxobacterial siderophore termed sorangibactin was discovered by heterologous expression of a coelibactin-like nonribosomal peptide synthetase (NRPS) gene cluster from the Sorangiineae strain MSr11367 in the host Myxococcus xanthus DK1622. De… read more here.
Keywords: myxobacterial thiolactone; discovery myxobacterial; guided discovery; thiolactone ... See more keywords
Computation-Guided Discovery of Diazole Monosubstituted Tetrazines as Optimal Bioorthogonal Tools.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c07958
Abstract: Monosubstituted tetrazines are important bioorthogonal reactive tools due to their rapid ligation with trans-cyclooctene. However, their application is limited by the reactivity-stability paradox in biological environments. In this study, we demonstrated that steric effects are… read more here.
Keywords: computation guided; guided discovery; trans cyclooctene; monosubstituted tetrazines ... See more keywords
Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-15876-y
Abstract: NPSL2 is a stem loop element within the oncomiR-1 polycistronic primary microRNA (miRNA) cluster. NPSL2 is predicted to mediate conformational rearrangements within oncomiR-1 to regulate the biogenesis of certain miRNA elements within the cluster. The… read more here.
Keywords: molecule; guided discovery; molecule ligands; structure guided ... See more keywords
Guided Discovery Learning-Based Chemistry E-Module and Its Effect on Students' Higher-Order Thinking Skills
Sign Up to like & getrecommendations! Published in 2023 at "Jurnal Pendidikan IPA Indonesia"
DOI: 10.15294/jpii.v12i1.42130
Abstract: This study aims to analyze the effectiveness of guided discovery learning-based e-modules in improving senior high school students' higher-order thinking skills. It belongs to quasi-experimental research with a non-randomized control-group pretest-posttest design. Three schools in… read more here.
Keywords: higher order; chemistry; guided discovery; order thinking ... See more keywords
Effect of scaffolding strategies and guided discovery on higher-order thinking skills in physics education
Sign Up to like & getrecommendations! Published in 2024 at "Eurasia Journal of Mathematics, Science and Technology Education"
DOI: 10.29333/ejmste/14980
Abstract: Embedding higher-order thinking within science education, particularly in teaching physics, can equip students to learn physics at a deeper level and to become active learners who can analyze and solve problems independently. The present research… read more here.
Keywords: scaffolding strategies; higher order; order thinking; guided discovery ... See more keywords
Professional Support in Teaching Mathematics through Guided Discovery: The Role of Agency on Multiple Levels
Sign Up to like & getrecommendations! Published in 2024 at "Education Sciences"
DOI: 10.3390/educsci14070769
Abstract: The paper describes a case study of mentoring support provided to a novice mathematics teacher in using Guided Discovery in her classroom. The study used qualitative methods: thematic analysis of interviews and discussions. A central… read more here.
Keywords: guided discovery; teacher agency; agency; mathematics ... See more keywords
Genome-Guided Discovery of the First Myxobacterial Biarylitide Myxarylin Reveals Distinct C–N Biaryl Crosslinking in RiPP Biosynthesis
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26247483
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a structurally diverse group of natural products. They feature a wide range of intriguing post-translational modifications, as exemplified by the biarylitides. These are a family of cyclic… read more here.
Keywords: guided discovery; myxarylin; biarylitide; biaryl ... See more keywords