Chemoinformatic-guided engineering of polyketide synthases.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c02549
Abstract: Polyketide synthase (PKS) engineering is an attractive method to generate new molecules such as commodity, fine and spe-cialty chemicals. A significant challenge in PKS design is engineering a partially reductive module to produce a saturated… read more here.
Keywords: engineering; reductive loops; guided engineering; engineering polyketide ... See more keywords
Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122105119
Abstract: Significance Inflammatory diseases collectively account for numerous deaths and morbidity worldwide. New treatment approaches are needed. A central feature of inflammatory diseases is the recruitment of leukocytes to the affected tissues, which is stimulated by… read more here.
Keywords: structure guided; tick evasins; guided engineering; structure ... See more keywords