Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria††Electronic supplementary information (ESI) available. CCDC 1831467 and 1831468. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8sc01325j
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DOI: 10.1039/c8sc01325j
Abstract: Mining the genome to harvest from the metabolome: a well-directed search for bioactive natural products unearths the pyxidicyclines from Pyxidicoccus. read more here.
Keywords: resistance guided; genome mining; uncovers new; mining uncovers ... See more keywords
Therapeutic applications of CRISPR RNA-guided genome editing.
Sign Up to like & getrecommendations! Published in 2017 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elw032
Abstract: The rapid development of programmable nuclease-based genome editing technologies has enabled targeted gene disruption and correction both in vitro and in vivo This revolution opens up the possibility of precise genome editing at target genomic… read more here.
Keywords: genome editing; crispr rna; therapeutic applications; rna guided ... See more keywords