Bioactivity-guided mixed synthesis accelerate the serendipity in lead optimization: Discovery of fungicidal homodrimanyl amides.
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DOI: 10.1016/j.ejmech.2017.04.073
Abstract: The bioactivity-guided mixed synthesis was conceived, in which the designed mix-reactions were run in parallel for simultaneous construction of different kinds of analogs. The valuable ones were protruded by biological screening. This tactic will facilitate… read more here.
Keywords: guided mixed; bioactivity guided; chemistry; optimization ... See more keywords