Structure-Guided Modification of Heterocyclic Antagonists of the P2Y14 Receptor.
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DOI: 10.1021/acs.jmedchem.8b00168
Abstract: The P2Y14 receptor (P2Y14R) mediates inflammatory activity by activating neutrophil motility, but few classes of antagonists are known. We have explored the structure-activity relationship of a 3-(4-phenyl-1 H-1,2,3-triazol-1-yl)-5-(aryl)benzoic acid antagonist scaffold, assisted by docking and… read more here.
Keywords: guided modification; structure guided; phenyl; p2y14 receptor ... See more keywords