Evolution-guided protein design of IscB for persistent epigenome editing in vivo.
Sign Up to like & getrecommendations! Published in 2025 at "Nature biotechnology"
DOI: 10.1038/s41587-025-02655-3
Abstract: Naturally existing enzymes have been adapted for a variety of molecular technologies, with enhancements or modifications to the enzymes introduced to improve the desired function; however, it is difficult to engineer variants with enhanced activity… read more here.
Keywords: protein design; guided protein; evolution guided; design iscb ... See more keywords
Distance-guided protein folding based on generalized descent direction.
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab296
Abstract: Advances in the prediction of the inter-residue distance for a protein sequence have increased the accuracy to predict the correct folds of proteins with distance information. Here, we propose a distance-guided protein folding algorithm based… read more here.
Keywords: direction; distance; guided protein; protein folding ... See more keywords
Expert-guided protein language models enable accurate and blazingly fast fitness prediction
Sign Up to like & getrecommendations! Published in 2024 at "Bioinformatics"
DOI: 10.1101/2024.04.24.590982
Abstract: Exhaustive experimental annotation of the effect of all known protein variants remains daunting and expensive, stressing the need for scalable effect predictions. We introduce VespaG, a blazingly fast missense amino acid variant effect predictor, leveraging… read more here.
Keywords: expert guided; effect; guided protein; blazingly fast ... See more keywords