Dynamic Covalent Template-Guided Screen for Nucleic Acid-Targeting Agents.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01086
Abstract: Trinucleotide repeat diseases such as myotonic dystrophy type 1 (DM1) and Huntington's disease (HD) are caused by expanded DNA repeats that can be used as templates to synthesize their own inhibitors. Because it would be… read more here.
Keywords: nucleic acid; dynamic covalent; chemistry; acid targeting ... See more keywords
An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3001977
Abstract: Failures in mitophagy, a process by which damaged mitochondria are cleared, results in neurodegeneration, while enhancing mitophagy promotes the survival of dopaminergic neurons. Using an artificial intelligence platform, we employed a natural language processing approach… read more here.
Keywords: lipid droplets; mitochondrial damage; mitophagy; probucol ... See more keywords