Kinetic Target‐Guided Synthesis of Small‐Molecule G‐Quadruplex Stabilizers
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DOI: 10.1002/open.202000261
Abstract: Abstract The formation of a G‐quadruplex motif in the promoter region of the c‐MYC protooncogene prevents its expression. Accordingly, G‐quadruplex stabilization by a suitable ligand may be a viable approach for anticancer therapy. In our… read more here.
Keywords: target guided; guided synthesis; molecule; kinetic target ... See more keywords
Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies.
Sign Up to like & getrecommendations! Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00568
Abstract: Kinetic target-guided synthesis (KTGS) is a promising tool for the discovery of biologically active compounds. It relies on the identification of potent ligands that are covalently assembled by the biological targets themselves from a pool… read more here.
Keywords: guided synthesis; target guided; chemistry; kinetic target ... See more keywords
Going beyond Binary: Rapid Identification of Protein-Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00108
Abstract: Kinetic target-guided synthesis (KTGS) is a powerful screening approach that enables identification of small molecule modulators for biomolecules. While many KTGS variants have emerged, a majority of the examples suffer from limited throughput and a… read more here.
Keywords: ktgs; guided synthesis; kinetic target; target guided ... See more keywords
Cell-Based Kinetic Target-Guided Synthesis of an Enzyme Inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.7b00535
Abstract: Finding a new drug candidate for a selected target is an expensive and time-consuming process. Target guided-synthesis, or in situ click chemistry, is a concept where the drug target is used to template the formation… read more here.
Keywords: guided synthesis; target guided; chemistry; target ... See more keywords