Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2020.0640
Abstract: Importance Despite evidence that guideline-directed medical therapy (GDMT) improves outcomes in patients with heart failure (HF) and reduced ejection fraction, many patients are undertreated. The Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment (GUIDE-IT) trial tested… read more here.
Keywords: trial; guideline directed; analysis; medical therapy ... See more keywords
The effect of kidney function on guideline‐directed medical therapy implementation and prognosis in heart failure with reduced ejection fraction
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DOI: 10.1002/clc.24244
Abstract: Kidney dysfunction (KD) is a main limiting factor of applying guideline‐directed medical therapy (GDMT) and reaching the recommended target doses (TD) in heart failure (HF) with reduced ejection fraction (HFrEF). read more here.
Keywords: reduced ejection; medical therapy; failure reduced; guideline directed ... See more keywords
Multimorbidity, guideline‐directed medical therapies, and associated outcomes among hospitalized heart failure patients
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DOI: 10.1002/ehf2.13954
Abstract: Multimorbidity is common among heart failure (HF) patients and may attenuate guideline‐directed medical therapy (GDMT). Multimorbid patients are under‐represented in clinical trials; therefore, the effect of multimorbidity clustering on the prognosis of HF patients remains… read more here.
Keywords: guideline directed; multimorbidity; heart failure; failure patients ... See more keywords
Reduction of heart failure guideline‐directed medication during hospitalization: prevalence, risk factors, and outcomes
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DOI: 10.1002/ehf2.14051
Abstract: Optimal management of heart failure with reduced ejection fraction (HFrEF) includes titration of guideline‐directed medical therapy (GDMT) to the highest tolerated dose within the licensed range. During hospitalization, GDMT doses are often significantly altered, although… read more here.
Keywords: hospitalization; guideline directed; heart failure; heart ... See more keywords
Frailty interferes with the guideline‐directed medical therapy in heart failure patients with reduced ejection fraction
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DOI: 10.1002/ehf2.14163
Abstract: Guideline‐directed medical therapy (GDMT) in patients with heart failure with reduced ejection fraction (HFrEF) is recommended in clinical guidelines, but elderly patients have not fully received GDMT in the clinical situation. The aim of this… read more here.
Keywords: heart failure; directed medical; guideline directed; heart ... See more keywords
A practical approach to the guideline‐directed pharmacological treatment of heart failure with reduced ejection fraction
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DOI: 10.1002/ehf2.14197
Abstract: Over the last 15–20 years, remarkable developments of heart failure (HF) pharmacotherapies have been achieved. However, HF remains a global healthcare challenge with more than 64 million patients worldwide. Optimization of guideline‐directed chronic HF medical… read more here.
Keywords: heart failure; guideline directed; ejection fraction; heart ... See more keywords
Socio‐economic status and the effect of guideline‐directed medical therapy in the STRONG‐HF study
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DOI: 10.1002/ehf2.15156
Abstract: Acute heart failure (AHF) impacts millions globally, with outcomes varying based on socio‐economic status (SES). read more here.
Keywords: effect guideline; guideline directed; economic status; socio economic ... See more keywords
Guideline‐directed medical therapy rates in heart failure patients with reduced ejection fraction in a diverse cohort
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DOI: 10.1002/ehf2.15193
Abstract: Guideline‐directed medical therapy (GDMT) is recommended for all patients with heart failure with reduced ejection fraction (HFrEF). Despite this, little data exist describing GDMT use in diverse, real‐world populations including the use of vasodilators, prescribed… read more here.
Keywords: heart; medical therapy; guideline directed; heart failure ... See more keywords
Real‐world use of guideline‐directed therapy for heart failure: Insights from the Danish Heart Failure Registry
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DOI: 10.1002/ehf2.15320
Abstract: We aimed to assess real‐world implementation of guideline‐directed medical therapy (GDMT) for heart failure (HF) with reduced ejection fraction (HFrEF) and its association with mortality and hospitalization. read more here.
Keywords: guideline directed; heart; real world; heart failure ... See more keywords
Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure in elderly patients: a sub-analysis of the STRONG-HF randomized clinical trial.
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DOI: 10.1002/ejhf.2920
Abstract: AIMS STRONG-HF examined a high-intensity care (HIC) strategy of rapid up-titration of guideline-directed medical therapy (GDMT) and close follow-up after acute heart failure (AHF) admission. We assess the role of age on efficacy and safety… read more here.
Keywords: titration guideline; older patients; guideline directed; heart failure ... See more keywords
Implementation of guideline‐directed medical therapy for heart failure
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DOI: 10.1002/ejhf.3343
Abstract: This article refers to ‘Contemporary guideline-directed medical therapy in de novo, chronic, and worsening heart failure patients: First data from the TITRATE-HF study’ by J. Malgie et al. , published in Eur J Heart Fail… read more here.
Keywords: heart; medical therapy; guideline directed; heart failure ... See more keywords