Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial.
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DOI: 10.1001/jamacardio.2020.0640
Abstract: Importance Despite evidence that guideline-directed medical therapy (GDMT) improves outcomes in patients with heart failure (HF) and reduced ejection fraction, many patients are undertreated. The Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment (GUIDE-IT) trial tested… read more here.
Keywords: trial; guideline directed; analysis; medical therapy ... See more keywords
Multimorbidity, guideline‐directed medical therapies, and associated outcomes among hospitalized heart failure patients
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DOI: 10.1002/ehf2.13954
Abstract: Multimorbidity is common among heart failure (HF) patients and may attenuate guideline‐directed medical therapy (GDMT). Multimorbid patients are under‐represented in clinical trials; therefore, the effect of multimorbidity clustering on the prognosis of HF patients remains… read more here.
Keywords: guideline directed; multimorbidity; heart failure; failure patients ... See more keywords
Reduction of heart failure guideline‐directed medication during hospitalization: prevalence, risk factors, and outcomes
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DOI: 10.1002/ehf2.14051
Abstract: Optimal management of heart failure with reduced ejection fraction (HFrEF) includes titration of guideline‐directed medical therapy (GDMT) to the highest tolerated dose within the licensed range. During hospitalization, GDMT doses are often significantly altered, although… read more here.
Keywords: hospitalization; guideline directed; heart failure; heart ... See more keywords
Frailty interferes with the guideline‐directed medical therapy in heart failure patients with reduced ejection fraction
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DOI: 10.1002/ehf2.14163
Abstract: Guideline‐directed medical therapy (GDMT) in patients with heart failure with reduced ejection fraction (HFrEF) is recommended in clinical guidelines, but elderly patients have not fully received GDMT in the clinical situation. The aim of this… read more here.
Keywords: heart failure; directed medical; guideline directed; heart ... See more keywords
A practical approach to the guideline‐directed pharmacological treatment of heart failure with reduced ejection fraction
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DOI: 10.1002/ehf2.14197
Abstract: Over the last 15–20 years, remarkable developments of heart failure (HF) pharmacotherapies have been achieved. However, HF remains a global healthcare challenge with more than 64 million patients worldwide. Optimization of guideline‐directed chronic HF medical… read more here.
Keywords: heart failure; guideline directed; ejection fraction; heart ... See more keywords
Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure in elderly patients: a sub-analysis of the STRONG-HF randomized clinical trial.
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DOI: 10.1002/ejhf.2920
Abstract: AIMS STRONG-HF examined a high-intensity care (HIC) strategy of rapid up-titration of guideline-directed medical therapy (GDMT) and close follow-up after acute heart failure (AHF) admission. We assess the role of age on efficacy and safety… read more here.
Keywords: titration guideline; older patients; guideline directed; heart failure ... See more keywords
Guideline-directed Medical Therapy May Not Be Harmful In Patients with Transthyretin Cardiac Amyloidosis and Heart Failure with Reduced Ejection Fraction
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DOI: 10.1016/j.cardfail.2020.09.372
Abstract: Introduction No guidelines exist on the use of guideline-directed medical therapy (GDMT) in the setting of transthyretin cardiac amyloidosis (TTR CA) and HFrEF, and its use remains controversial. There is no survival data demonstrating the… read more here.
Keywords: gdmt; ttr hfref; may harmful; directed medical ... See more keywords
Impact of Non-guideline-directed Care on Quality of Life in Testicular Cancer Survivors.
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DOI: 10.1016/j.euf.2020.10.005
Abstract: BACKGROUND Non-guideline-directed care (NGDC) is seen in ∼30% of testicular cancer patients and has been identified as a significant predictor of relapse. However, the potential impact of mismanagement on patient quality of life (QoL) is… read more here.
Keywords: cancer; testicular cancer; quality life; guideline directed ... See more keywords
GUIDELINE-DIRECTED MEDICAL THERAPY BEFORE CRT: IS IT ALWAYS NECESSARY?
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DOI: 10.1016/s0735-1097(17)34203-1
Abstract: Background: Cardiac resynchronization therapy (CRT) is recommended for patients with reduced ejection fraction (EF) and left bundle branch block (LBBB) on guideline-directed medical therapy (GDMT) for at least 3 months. For a subset of patients… read more here.
Keywords: guideline directed; therapy crt; medical therapy; directed medical ... See more keywords
GUIDELINE-DIRECTED MEDICAL THERAPY INITIATION FOR HEART FAILURE WITH REDUCED EJECTION FRACTION DOES NOT VARY ACCORDING TO GERIATRIC CONDITIONS
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DOI: 10.1016/s0735-1097(20)31373-5
Abstract: Objective: To clarify the patient characteristics associated with seeking medical help for insomnia. Methods: A consecutive sample (n = 700) of adults attending a nonurgent primary care appointment was screened for sleep problems. A follow-up… read more here.
Keywords: therapy initiation; guideline directed; insomnia; medical therapy ... See more keywords
DOES GUIDELINE DIRECTED MEDICAL THERAPY FOR SYSTOLIC HEART FAILURE HELP PREVENT TAKOTSUBO RECURRENCE AND/OR READMSSION?
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DOI: 10.1016/s0735-1097(20)31506-0
Abstract: Takotsubo Syndrome (TTS) is a form of acute systolic cardiomyopathy, usually reversible, resembling an acute coronary syndrome but occurring in the absence of epicardial obstructive coronary artery disease. It commonly affects postmenopausal women after a… read more here.
Keywords: systolic heart; guideline directed; medical therapy; directed medical ... See more keywords