Gulp1 regulates chondrocyte growth arrest and differentiation via the TGF‐β/SMAD2/3 pathway
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Letters"
DOI: 10.1002/1873-3468.14862
Abstract: Chondrocyte differentiation is crucial for cartilage formation. However, the complex processes and mechanisms coordinating chondrocyte proliferation and differentiation remain incompletely understood. Here, we report a novel function of the adaptor protein Gulp1 in chondrocyte differentiation.… read more here.
Keywords: differentiation; smad2 pathway; tgf smad2; gulp1 ... See more keywords
Gulp1 deficiency augments bone mass in male mice by affecting osteoclasts due to elevated 17β‐estradiol levels
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30987
Abstract: The engulfment adaptor phosphotyrosine‐binding domain containing 1 (GULP1) is an adaptor protein involved in the engulfment of apoptotic cells via phagocytosis. Gulp1 was first found to promote the phagocytosis of apoptotic cells by macrophages, and… read more here.
Keywords: bone mass; gulp1; male; mice ... See more keywords
GULP1 Regulates Tendon Cell Proliferation and Maturation Essential for Motor Coordination in Mice
Sign Up to like & getrecommendations! Published in 2025 at "Acta Physiologica"
DOI: 10.1111/apha.70087
Abstract: Tendons are fibrous tissues connecting muscles to bones, providing joint stability and enabling movement. Adaptor proteins regulate cellular processes essential for maintaining tendon function. Phosphotyrosine‐binding domain‐containing engulfment adaptor protein 1 (GULP1) participates in multiple cellular… read more here.
Keywords: mice; regulates tendon; gulp1 regulates; tendon cell ... See more keywords