Synthesis and properties of oligonucleotides modified with an N-methylguanidine-bridged nucleic acid (GuNA[Me]) bearing adenine, guanine, or 5-methylcytosine nucleobases
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DOI: 10.3762/bjoc.17.54
Abstract: Chemical modifications have been extensively used for therapeutic oligonucleotides because they strongly enhance the stability against nucleases, binding affinity to the targets, and efficacy. We previously reported that oligonucleotides modified with an N-methylguanidine-bridged nucleic acid… read more here.
Keywords: bridged nucleic; methylguanidine bridged; guna; oligonucleotides modified ... See more keywords