Neonatal hyperbilirubinemia differentially alters the neurochemical profiles of the developing cerebellum and hippocampus in a preterm Gunn rat model.
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DOI: 10.1002/nbm.4946
Abstract: Neonatal hyperbilirubinemia (NHB) can lead to brain injury in newborn infants by affecting specific regions including the cerebellum and hippocampus. Extremely preterm infants (EPT) are more vulnerable to bilirubin neurotoxicity, but the mechanism and extent… read more here.
Keywords: cerebellum hippocampus; gunn rat; preterm; hippocampus ... See more keywords
A GUNN RAT MODEL OF PRETERM HYPERBILIRUBINEMIA
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DOI: 10.1038/s41390-019-0599-x
Abstract: Background The impact of bilirubin in preterm infants is poorly understood. An animal model would assist in improving understanding. The Gunn rat lacks uridine diphosphate-glucuronylsyl transferase 1 and can be made acutely hyperbilirubinemic by injection… read more here.
Keywords: sulfa group; model; rat model; gunn rat ... See more keywords
Curcumin Prevents Cerebellar Hypoplasia and Restores the Behavior in Hyperbilirubinemic Gunn Rat by a Pleiotropic Effect on the Molecular Effectors of Brain Damage
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DOI: 10.3390/ijms22010299
Abstract: Bilirubin toxicity to the central nervous system (CNS) is responsible for severe and permanent neurologic damage, resulting in hearing loss, cognitive, and movement impairment. Timely and effective management of severe neonatal hyperbilirubinemia by phototherapy or… read more here.
Keywords: gunn rat; damage; cerebellar hypoplasia; brain damage ... See more keywords