Development of a VP28-pseudotyped baculovirus expression system for efficient gene transfer in penaeid shrimps
Sign Up to like & getrecommendations! Published in 2021 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2021.736741
Abstract: Abstract Both efficient gene transfer and expression tools and suitable reporter genes are lacking for penaeid shrimps and their isolated cells. In this study a VP28-pseudotyped insect baculovirus expression system: Bacmid-GUS/VP28, carrying a reporter gene… read more here.
Keywords: expression; vp28; gene; gene transfer ... See more keywords
Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.01.013
Abstract: The human gut microbiota encodes β-glucuronidases (GUSs) that play key roles in health and disease via the metabolism of glucuronate-containing carbohydrates and drugs. Hundreds of putative bacterial GUS enzymes have been identified by metagenomic analysis… read more here.
Keywords: gus; human gut; fmn binding; site ... See more keywords
A New Fluorescent Probe Tool: ERNathG.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c00075
Abstract: β-d-Glucuronidase (GUS) plays a pivotal role in both clinical treatment assessment and environmental monitoring. Existing tools for GUS detection suffer from (1) poor continuity due to a gap between the optimal pH of the probes… read more here.
Keywords: gus; probe tool; fluorescent probe; new fluorescent ... See more keywords
Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate
Sign Up to like & getrecommendations! Published in 2022 at "Gut Microbes"
DOI: 10.1080/19490976.2022.2107289
Abstract: ABSTRACT Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximately 45%… read more here.
Keywords: mycophenolate; enzymes reactivate; gus; activity based ... See more keywords
Microbial β-glucuronidases drive human periodontal disease etiology
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adg3390
Abstract: Periodontitis is a chronic inflammatory disease associated with persistent oral microbial dysbiosis. The human β-glucuronidase (GUS) degrades constituents of the periodontium and is used as a biomarker for periodontitis severity. However, the human microbiome also… read more here.
Keywords: microbial glucuronidases; disease; periodontal disease; etiology ... See more keywords
AB0772 EFFICACY OF GUSELKUMAB IN PSORIASIS PATIENTS WITH SELF-REPORTED PSORIATIC ARTHRITIS WITH INVOLVEMENT OF THE SCALP, NAILS, HANDS, AND FEET: A POOLED ANALYSIS FROM 2 PIVOTAL PHASE 3 PSORIASIS STUDIES
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.183
Abstract: Background VOYAGE 1 & 2 were the pivotal Ph3 GUS trials for plaque psoriasis (PsO).1,2 Objectives Here we compare efficacy of GUS vs PBO & vs adalimumab (ADA) on PsO involving scalp, nail & palmoplantar… read more here.
Keywords: gus; pso; pga; psoriasis ... See more keywords
β-Glucuronidase Pattern Predicted From Gut Metagenomes Indicates Potentially Diversified Pharmacomicrobiomics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.826994
Abstract: β-glucuronidases (GUS) of intestinal bacteria remove glucuronic acid from glucoronides, reversing phase II metabolism of the liver and affecting the level of active deconjugated metabolites deriving from drugs or xenobiotics. Two hundred seventy-nine non-redundant GUS… read more here.
Keywords: gus; gut metagenomes; pattern predicted; glucuronidase pattern ... See more keywords