Highly efficient CRISPR-mediated base editing for the gut Bacteroides spp. with pnCasBS-CBE.
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DOI: 10.1002/biot.202200504
Abstract: Bacteroidales are the most abundant order of bacteria in the healthy human gut and have the potential as a therapeutic agent. We constructed a pnCasBS-CBE system for base editing in the Bacteroides thetaiotaomicron to expand… read more here.
Keywords: system; gut bacteroides; cbe; base editing ... See more keywords
Plant N-glycan breakdown by human gut Bacteroides
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208168119
Abstract: The major nutrients available to the human colonic microbiota are complex glycans derived from the diet. To degrade this highly variable mix of sugar structures, gut microbes have acquired a huge array of different carbohydrate-active… read more here.
Keywords: gut bacteroides; plant glycans; plant glycan; plant ... See more keywords
Structural and Biochemical Characterization of a Nonbinding SusD-Like Protein Involved in Xylooligosaccharide Utilization by an Uncultured Human Gut Bacteroides Strain
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DOI: 10.1128/msphere.00244-22
Abstract: The metabolization of dietary fiber is a crucial function for many gut bacteria, especially Bacteroidetes, which are particularly well adapted for recognizing, binding, transporting, and degrading glycosides. In this study, we report the functional and… read more here.
Keywords: susd like; gut bacteroides; utilization; like protein ... See more keywords
Nutrient niche specificity for glycosaminoglycans is reflected in polysaccharide utilization locus architecture of gut Bacteroides species
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DOI: 10.3389/fmicb.2022.1033355
Abstract: Introduction Glycosaminoglycans (GAGs) present in the mucosal layer can be used as nutrients by certain intestinal bacteria, particularly members of the Bacteroides. GAG abundances are altered in some diseases such as inflammatory bowel diseases, which… read more here.
Keywords: gut bacteroides; niche specificity; nutrient niche; utilization ... See more keywords
Human gut Bacteroides capture vitamin B12 via cell surface-exposed lipoproteins
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DOI: 10.7554/elife.37138
Abstract: Human gut Bacteroides use surface-exposed lipoproteins to bind and metabolize complex polysaccharides. Although vitamins and other nutrients are also essential for commensal fitness, much less is known about how commensal bacteria compete with each other… read more here.
Keywords: surface exposed; human gut; b12; exposed lipoproteins ... See more keywords