Peanut Skin Procyanidins Ameliorates Insulin resistance via Modulation of Gut Microbiota and Gut Barrier in Type 2 Diabetic Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11945
Abstract: BACKGROUND Peanut skin procyanidins (PSP) have been shown to possess anti-diabetic activities. However, the mechanism remains poorly understood due to its low bioavailability. This study aims to investigate the preventive effect of PSP on type… read more here.
Keywords: gut; peanut skin; gut microbiota; mice ... See more keywords
Building Fences: How A20 Protects the Intestinal Mucosa in Inflammatory Bowel Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05964-1
Abstract: Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), are chronic diseases with no definite cure found to date. The etiology of IBD is complex, as many factors are associated with disease… read more here.
Keywords: inflammatory bowel; inflammation; bowel diseases; ibd ... See more keywords
The role of mucosal barriers in human gut health.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of pharmacal research"
DOI: 10.1007/s12272-021-01327-5
Abstract: The intestinal mucosa is continuously exposed to a large number of commensal or pathogenic microbiota and foreign food antigens. The intestinal epithelium forms a dynamic physicochemical barrier to maintain immune homeostasis. To efficiently absorb nutrients… read more here.
Keywords: mucosal barriers; human gut; barriers human; role mucosal ... See more keywords
Gut Dysbiosis Increases Gut Barrier Damage during Anti-Leukemia Chemotherapy: Implications for Acute Graft-Versus-Host Disease
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.433
Abstract: We recently reported an association between low pre-conditioning serum citrulline, reflecting unresolved gut barrier injury from prior chemotherapy, and higher incidence of grade II-IV acute graft-versus-host disease (aGVHD). Citrulline is an amino acid exclusively synthesized… read more here.
Keywords: chemotherapy; citrulline; acute graft; barrier damage ... See more keywords
Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.008
Abstract: Glucagon-like peptide 1 (GLP-1) is a hormone released from enteroendocrine L cells. Although first described as a glucoregulatory incretin hormone, GLP-1 also suppresses inflammation and promotes mucosal integrity. Here, we demonstrate that plasma GLP-1 levels… read more here.
Keywords: secretion; glp; enteroendocrine cells; gut barrier ... See more keywords
Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial: Arabinoxylans in gut barrier.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical nutrition"
DOI: 10.1016/j.clnu.2017.01.024
Abstract: BACKGROUND & AIMS Obesity and metabolic diseases are associated with alterations in microbial composition and impaired gut barrier. Previous in vitro and animal studies have shown that arabinoxylans (AX) have the potential to modulate gut microbiota… read more here.
Keywords: overweight obese; transcription; barrier; controlled trial ... See more keywords
Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.03.037
Abstract: ABSTRACT Stress‐induced altered visceral sensation and impaired gut barrier play an important role in the pathophysiology of irritable bowel syndrome (IBS). These responses were demonstrated to be peripheral corticotropin‐releasing factor (CRF) dependent and also mediated… read more here.
Keywords: gut barrier; stress induced; model; antagonist ... See more keywords
E-cigarettes compromise the gut barrier and trigger inflammation
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102035
Abstract: Summary E-cigarette usage continues to rise, yet the safety of e-cigarette aerosols is questioned. Using murine models of acute and chronic e-cigarette aerosol inhalation, murine colon transcriptomics, and murine and human gut-derived organoids in co-culture… read more here.
Keywords: inflammation; cigarettes compromise; gut barrier; cigarette ... See more keywords
Differential effects of inulin or its fermentation metabolites on gut barrier and immune function of porcine intestinal epithelial cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2020.103855
Abstract: Abstract Prebiotics can modulate gut fermentation and improve intestinal barrier function in mammals. First, inulin fermentation profile was tested in a three-step in vitro model of the piglet’s gastro-intestinal tract combining a hydrolysis – dialysis… read more here.
Keywords: gut barrier; inulin fermentation; differential effects; fermentation ... See more keywords
Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2020.01.018
Abstract: Objective Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase 1 B (PTP1B) plays distinct roles in non-immune… read more here.
Keywords: gut; ptp1b; mice; gut barrier ... See more keywords
Roles of gastrointestinal polypeptides in intestinal barrier regulation
Sign Up to like & getrecommendations! Published in 2022 at "Peptides"
DOI: 10.1016/j.peptides.2022.170753
Abstract: The intestinal barrier is a dynamic entity that is organized as a multilayer system and includes various intracellular and extracellular elements. The gut barrier functions in a coordinated manner to impede the passage of antigens,… read more here.
Keywords: gastrointestinal polypeptides; barrier; gut barrier; intestinal barrier ... See more keywords