Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2022.4974
Abstract: Key Points Question To what extent are shared genetic determinants in the comorbidities and associations between gastrointestinal tract diseases and psychiatry disorders involved in the gut-brain axis? Findings In this genome-wide pleiotropic association study using… read more here.
Keywords: brain axis; shared genetic; etiology; gut brain ... See more keywords
Inflammation, Lifestyle Factors, and the Microbiome-Gut-Brain Axis: Relevance to Depression and Antidepressant Action.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2581
Abstract: Depression is considered a major public health concern, where existing pharmacological treatments are not equally effective across all patients. The pathogenesis of depression involves the interaction of complex biological components such as the immune system… read more here.
Keywords: gut brain; action; brain axis; depression ... See more keywords
[From gut feeling to visceral pain : Effects of negative expectations in the context of the gut-brain axis].
Sign Up to like & getrecommendations! Published in 2021 at "Schmerz"
DOI: 10.1007/s00482-021-00614-w
Abstract: Disturbances of the gut-brain axis are characterized by complex dysfunctions on peripheral and central nervous system levels, which can contribute to visceral hypervigilance and hyperalgesia and imprint visceral pain. Numerous cognitive, emotional and psychoneurobiological factors… read more here.
Keywords: gut brain; visceral pain; brain axis; pain ... See more keywords
The Role of Epigenomic Regulatory Pathways in the Gut-Brain Axis and Visceral Hyperalgesia.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-021-01108-0
Abstract: The gut-brain axis (GBA) is broadly accepted to describe the bidirectional circuit that links the gastrointestinal tract with the central nervous system (CNS). Interest in the GBA has grown dramatically over past two decades along… read more here.
Keywords: visceral hyperalgesia; hyperalgesia; brain axis; epigenomic regulatory ... See more keywords
Sex Differences in the Gut-Brain Axis: Implications for Mental Health
Sign Up to like & getrecommendations! Published in 2020 at "Current Psychiatry Reports"
DOI: 10.1007/s11920-020-01202-y
Abstract: Purpose of Review The purpose of this article is to highlight how sex differences in the gut-brain axis may contribute to the discrepancies in incidence of neurodevelopmental, psychiatric, and neurodegenerative disorders between females and males.… read more here.
Keywords: differences gut; sex differences; brain axis; sex ... See more keywords
Inflammasome-Regulated Pyroptotic Cell Death in Disruption of the Gut-Brain Axis After Stroke.
Sign Up to like & getrecommendations! Published in 2022 at "Translational stroke research"
DOI: 10.1007/s12975-022-01005-8
Abstract: Approximately 50% of stroke survivors experience gastrointestinal complications. The innate immune response plays a role in changes to the gut-brain axis after stroke. The purpose of this study is to examine the importance of inflammasome-mediated… read more here.
Keywords: gut brain; disruption gut; brain axis; stroke ... See more keywords
The microbiota-gut-brain axis: Focus on the fundamental communication pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2020.08.012
Abstract: Abstract The existence of a bidirectional communication system termed the “gut-brain axis” linking the gastrointestinal tract with the brain has been recognized since the nineteenth century. In the last decades, however, it has become evident… read more here.
Keywords: microbiota gut; communication; brain axis; brain ... See more keywords
Modeling gut-brain interactions in zebrafish
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2019.03.003
Abstract: Mounting clinical and experimental evidence suggests the gut-brain interplay as a novel important paradigm in translational neuroscience, including the critical role for gut microbiota in modulating brain development and behavior, as well as neuroimmune and… read more here.
Keywords: interactions zebrafish; modeling gut; brain interactions; brain ... See more keywords
A Specific Gut Microbiota Dysbiosis of Type 2 Diabetic Mice Induces GLP-1 Resistance through an Enteric NO-Dependent and Gut-Brain Axis Mechanism.
Sign Up to like & getrecommendations! Published in 2017 at "Cell metabolism"
DOI: 10.1016/j.cmet.2017.04.013
Abstract: Glucagon-like peptide-1 (GLP-1)-based therapies control glycemia in type 2 diabetic (T2D) patients. However, in some patients the treatment must be discontinued, defining a state of GLP-1 resistance. In animal models we identified a specific set… read more here.
Keywords: gut brain; gut; glp resistance;
The gut-brain interaction in opioid tolerance.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2017.10.012
Abstract: The prevailing opioid crisis has necessitated the need to understand mechanisms leading to addiction and tolerance, the major contributors to overdose and death and to develop strategies for developing drugs for pain treatment that lack… read more here.
Keywords: tolerance; gut brain; brain interaction; pain ... See more keywords
Neuropeptides in gut-brain axis and their influence on host immunity and stress
Sign Up to like & getrecommendations! Published in 2020 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2020.02.018
Abstract: In recent decades, neuropeptides have been found to play a major role in communication along the gut-brain axis. Various neuropeptides are expressed in the central and peripheral nervous systems, where they facilitate the crosstalk between… read more here.
Keywords: immunity stress; brain axis; nervous systems; brain ... See more keywords