Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2019.04.037
Abstract: Summary We leveraged a human gut-on-a-chip (Gut Chip) microdevice that enables independent control of fluid flow and mechanical deformations to explore how physical cues and morphogen gradients influence intestinal morphogenesis. Both human intestinal Caco-2 and… read more here.
Keywords: gut chip; physical cues; intestinal morphogenesis; flow ... See more keywords
Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01490d
Abstract: Supplemental Bifidobacterium has been shown to aid in the prevention, alleviation, and treatment of inflammatory bowel disease (IBD), but the progression and mechanisms are largely unstudied, partly because of a lack of appropriate models. In… read more here.
Keywords: bifidobacterium bifidum; gut chip; bifidobacterium; oxygen ... See more keywords
A Biomimetic Human Gut‐on‐a‐Chip for Modeling Drug Metabolism in Intestine
Sign Up to like & getrecommendations! Published in 2018 at "Artificial Organs"
DOI: 10.1111/aor.13163
Abstract: Drug metabolism in the intestine is considered to substantially contribute to the overall first-pass metabolism, which has been neglected for a long time. It is highly desirable to develop a reliable model to evaluate drug… read more here.
Keywords: gut chip; human gut; metabolism; drug ... See more keywords
Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.877892
Abstract: Past studies on the protective effects of chitosan oligosaccharides (COS) on inflammatory bowel disease (IBD) commonly rely on animal models, because traditional cell culture systems couldn’t faithfully mimic human intestinal physiology. Here a novel human… read more here.
Keywords: chitosan oligosaccharides; gut chip; occurrence development; chip ... See more keywords
Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies
Sign Up to like & getrecommendations! Published in 2023 at "Biomimetics"
DOI: 10.3390/biomimetics8020226
Abstract: The gut plays a key role in drug absorption and metabolism of orally ingested drugs. Additionally, the characterization of intestinal disease processes is increasingly gaining more attention, as gut health is an important contributor to… read more here.
Keywords: research; intestinal disease; development; gut chip ... See more keywords
Microfluidic Gut-on-a-Chip: Fundamentals and Challenges
Sign Up to like & getrecommendations! Published in 2023 at "Biosensors"
DOI: 10.3390/bios13010136
Abstract: The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs. Advances in microfluidic technologies have made a significant impact on… read more here.
Keywords: chip fundamentals; gut; microfluidic gut; gut chip ... See more keywords
The Gut–Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044089
Abstract: The intestine is considered to be a vital digestive organ to absorb nutrients and is the largest immune organ, while numerous microorganisms coexist with the host. It is well known that the complex interactions between… read more here.
Keywords: gut; gut chip; organ axis; axis gut ... See more keywords
Effects of Porous Size and Membrane Pattern on Shear Stress Characteristic in Gut-on-a-Chip with Peristalsis Motion
Sign Up to like & getrecommendations! Published in 2022 at "Micromachines"
DOI: 10.3390/mi14010022
Abstract: Dynamic gut-on-a-chip platform allows better recreation of the intestinal environment in vitro compared to the traditional static cell culture. However, the underlying mechanism is still not fully discovered. In this study, the shear stress behavior… read more here.
Keywords: stress; gut chip; size; membrane ... See more keywords
Gut-on-a-Chip for the Analysis of Bacteria–Bacteria Interactions in Gut Microbial Community: What Would Be Needed for Bacterial Co-Culture Study to Explore the Diet–Microbiota Relationship?
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15051131
Abstract: Bacterial co-culture studies using synthetic gut microbiomes have reported novel research designs to understand the underlying role of bacterial interaction in the metabolism of dietary resources and community assembly of complex microflora. Since lab-on-a-chip mimicking… read more here.
Keywords: bacterial culture; gut chip; chip; research ... See more keywords