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   Articles with "gut chip" as a keyword



Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip

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recommendations! Published in 2019 at "iScience"

DOI: 10.1016/j.isci.2019.04.037

Abstract: Summary We leveraged a human gut-on-a-chip (Gut Chip) microdevice that enables independent control of fluid flow and mechanical deformations to explore how physical cues and morphogen gradients influence intestinal morphogenesis. Both human intestinal Caco-2 and… read more here.

Keywords: gut chip; physical cues; intestinal morphogenesis; flow ... See more keywords

Gut-on-a-Chip-Based Real-Time miRNA-21 Monitoring and Anti-Inflammatory Drug Evaluation.

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recommendations! Published in 2025 at "ACS sensors"

DOI: 10.1021/acssensors.5c00957

Abstract: MiRNA-21 is a crucial biomarker involved in inflammatory pathways and is linked to gastrointestinal diseases like inflammatory bowel disease (IBD). Its dynamic expression reflects disease progression and treatment response, making it an attractive target for… read more here.

Keywords: drug; monitoring; chip; anti inflammatory ... See more keywords

A high-throughput gut-on-chip platform to study the epithelial responses to enterotoxins

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-56520-5

Abstract: Enterotoxins are a type of toxins that primarily affect the intestines. Understanding their harmful effects is essential for food safety and medical research. Current methods lack high-throughput, robust, and translatable models capable of characterizing toxin-specific… read more here.

Keywords: high throughput; study; throughput gut; chip platform ... See more keywords

Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease.

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recommendations! Published in 2023 at "Biomaterials science"

DOI: 10.1039/d2bm01490d

Abstract: Supplemental Bifidobacterium has been shown to aid in the prevention, alleviation, and treatment of inflammatory bowel disease (IBD), but the progression and mechanisms are largely unstudied, partly because of a lack of appropriate models. In… read more here.

Keywords: bifidobacterium bifidum; gut chip; bifidobacterium; oxygen ... See more keywords

Biofabrication and simulation techniques for gut-on-a-chip

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recommendations! Published in 2025 at "Biofabrication"

DOI: 10.1088/1758-5090/adb7c1

Abstract: Biomimetic gut models show promise for enhancing our understanding of intestinal disorder pathogenesis and accelerating therapeutic strategy development. Current in vitro models predominantly comprise traditional static cell culture and animal models. Static cell culture lacks… read more here.

Keywords: simulation techniques; culture; techniques gut; biofabrication simulation ... See more keywords

A Biomimetic Human Gut‐on‐a‐Chip for Modeling Drug Metabolism in Intestine

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recommendations! Published in 2018 at "Artificial Organs"

DOI: 10.1111/aor.13163

Abstract: Drug metabolism in the intestine is considered to substantially contribute to the overall first-pass metabolism, which has been neglected for a long time. It is highly desirable to develop a reliable model to evaluate drug… read more here.

Keywords: gut chip; human gut; metabolism; drug ... See more keywords

Chitosan Oligosaccharides Regulate the Occurrence and Development of Enteritis in a Human Gut-On-a-Chip

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.877892

Abstract: Past studies on the protective effects of chitosan oligosaccharides (COS) on inflammatory bowel disease (IBD) commonly rely on animal models, because traditional cell culture systems couldn’t faithfully mimic human intestinal physiology. Here a novel human… read more here.

Keywords: chitosan oligosaccharides; gut chip; occurrence development; chip ... See more keywords

Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies

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recommendations! Published in 2023 at "Biomimetics"

DOI: 10.3390/biomimetics8020226

Abstract: The gut plays a key role in drug absorption and metabolism of orally ingested drugs. Additionally, the characterization of intestinal disease processes is increasingly gaining more attention, as gut health is an important contributor to… read more here.

Keywords: research; intestinal disease; development; gut chip ... See more keywords

Microfluidic Gut-on-a-Chip: Fundamentals and Challenges

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recommendations! Published in 2023 at "Biosensors"

DOI: 10.3390/bios13010136

Abstract: The human gut is responsible for food digestion and absorption. Recently, growing evidence has shown its vital role in the proper functioning of other organs. Advances in microfluidic technologies have made a significant impact on… read more here.

Keywords: chip fundamentals; gut; microfluidic gut; gut chip ... See more keywords

The Gut–Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24044089

Abstract: The intestine is considered to be a vital digestive organ to absorb nutrients and is the largest immune organ, while numerous microorganisms coexist with the host. It is well known that the complex interactions between… read more here.

Keywords: gut; gut chip; organ axis; axis gut ... See more keywords

Effects of Porous Size and Membrane Pattern on Shear Stress Characteristic in Gut-on-a-Chip with Peristalsis Motion

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recommendations! Published in 2022 at "Micromachines"

DOI: 10.3390/mi14010022

Abstract: Dynamic gut-on-a-chip platform allows better recreation of the intestinal environment in vitro compared to the traditional static cell culture. However, the underlying mechanism is still not fully discovered. In this study, the shear stress behavior… read more here.

Keywords: stress; gut chip; size; membrane ... See more keywords