Secreted NF-κB suppressive microbial metabolites modulate gut inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110646
Abstract: Emerging evidence suggests that microbiome-host crosstalk regulates intestinal immune activity and predisposition to inflammatory bowel disease (IBD). NF-κB is a master regulator of immune function and a validated target for the treatment of IBD. Here,… read more here.
Keywords: secreted suppressive; suppressive microbial; microbial metabolites; gut inflammation ... See more keywords
CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.10.013
Abstract: CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-chemotaxis functions of CCR6 signaling… read more here.
Keywords: induced treg; gut inflammation; ccr6; ccr6 signaling ... See more keywords
Dietary phytochemicals as regulators of gut inflammation in the context of type 2 diabetes
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the Nutrition Society"
DOI: 10.1017/s0029665124002088
Abstract: Numerous disorders, including type 2 diabetes and even COVID-19, are linked to poor gut health and inflammation(1,2). In addition to impacting food digestion and absorption, gut inflammation worsens diabetes outcomes by causing gut microbial dysbiosis,… read more here.
Keywords: ace2; type diabetes; gut inflammation; inflammation ... See more keywords
Helminth driven gut inflammation and microbial translocation associate with altered vaccine responses in rural Uganda
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Vaccines"
DOI: 10.1038/s41541-025-01116-x
Abstract: Vaccine responses are sometimes impaired in rural, low-income settings. Helminth-associated gut barrier dysfunction and microbial translocation (MT) may be implicated. We used samples from a trial of praziquantel treatment-effects on vaccine responses in Schistosoma mansoni… read more here.
Keywords: gut inflammation; fob; vaccine responses; microbial translocation ... See more keywords
Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigates gut inflammation via inhibiting the differentiation of CD4+ T cells.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr05644a
Abstract: Proinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) are critical mediators of inflammatory bowel disease pathogenesis, and are important targets to restore intestinal homeostasis. Herein, we present the engineering and screening of gemini lipid nanoparticles… read more here.
Keywords: gemini lipid; gut inflammation; cd4 cells; sirna ... See more keywords
Mediterranean-like dietary pattern associations with gut microbiome composition and sub-clinical gastrointestinal inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.05.037
Abstract: BACKGROUND AND AIMS Case-control studies have shown that Crohn's disease (CD) patients have a different microbial composition than healthy individuals. Although the causes of CD are unknown, epidemiological studies suggest that diet is an important… read more here.
Keywords: dietary patterns; inflammation; gut inflammation; composition ... See more keywords
Dexamethasone Upregulates the Expression of the Human SLC26A3 (DRA, Down-Regulated in Adenoma) Transporter (an IBD Susceptibility Gene) in Intestinal Epithelial Cells and Attenuates Gut Inflammation.
Sign Up to like & getrecommendations! Published in 2024 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izae271
Abstract: BACKGROUND Down-Regulated in Adenoma (DRA) plays a critical role in intestinal chloride absorption and a decrease in its expression is a key event in diarrheal disorders. Recently, DRA has emerged as an Inflammatory Bowel Disease (IBD)… read more here.
Keywords: dex; expression; dra; dra expression ... See more keywords
All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation.
Sign Up to like & getrecommendations! Published in 2019 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izz249
Abstract: BACKGROUND Intestinal epithelial apical membrane Cl-/HCO3- exchanger DRA (downregulated in adenoma, SLC26A3) has emerged as an important therapeutic target for diarrhea, emphasizing the potential therapeutic role of agents that upregulate DRA. All-trans retinoic acid (ATRA),… read more here.
Keywords: trans retinoic; gut inflammation; dra; expression ... See more keywords
Anti-CD74 IgA antibodies show diagnostic potential for axial spondyloarthritis but are not associated with microscopic gut inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac384
Abstract: OBJECTIVES Gut inflammation commonly occurs in axial spondyloarthritis (axSpA), and is linked to disease activity and outcome. Given the role of IgA in mucosal immunity, we explored the association between anti-CD74 IgA antibodies, gut inflammation… read more here.
Keywords: anti cd74; gut inflammation; axspa; cd74 iga ... See more keywords
Infant Feeding, Gut Permeability, and Gut Inflammation Markers
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pediatric Gastroenterology and Nutrition"
DOI: 10.1097/mpg.0000000000003756
Abstract: Objectives: Increased gut permeability and gut inflammation have been linked to the development of type 1 diabetes. Little is known on whether and how intake of different foods is linked to these mechanisms in infancy.… read more here.
Keywords: gut inflammation; gut; permeability gut; gut permeability ... See more keywords
Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16102
Abstract: Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well‐publicized guidelines for its early detection and treatment. It is recognized that the gut may aggravate… read more here.
Keywords: gut inflammation; gut; liver; toxicity ... See more keywords