Secreted NF-κB suppressive microbial metabolites modulate gut inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2022.110646
Abstract: Emerging evidence suggests that microbiome-host crosstalk regulates intestinal immune activity and predisposition to inflammatory bowel disease (IBD). NF-κB is a master regulator of immune function and a validated target for the treatment of IBD. Here,… read more here.
Keywords: secreted suppressive; suppressive microbial; microbial metabolites; gut inflammation ... See more keywords
CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.10.013
Abstract: CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-chemotaxis functions of CCR6 signaling… read more here.
Keywords: induced treg; gut inflammation; ccr6; ccr6 signaling ... See more keywords
Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigates gut inflammation via inhibiting the differentiation of CD4+ T cells.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr05644a
Abstract: Proinflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) are critical mediators of inflammatory bowel disease pathogenesis, and are important targets to restore intestinal homeostasis. Herein, we present the engineering and screening of gemini lipid nanoparticles… read more here.
Keywords: gemini lipid; gut inflammation; cd4 cells; sirna ... See more keywords
Mediterranean-like dietary pattern associations with gut microbiome composition and sub-clinical gastrointestinal inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.05.037
Abstract: BACKGROUND AND AIMS Case-control studies have shown that Crohn's disease (CD) patients have a different microbial composition than healthy individuals. Although the causes of CD are unknown, epidemiological studies suggest that diet is an important… read more here.
Keywords: dietary patterns; inflammation; gut inflammation; composition ... See more keywords
All-trans Retinoic Acid Counteracts Diarrhea and Inhibition of Downregulated in Adenoma Expression in Gut Inflammation.
Sign Up to like & getrecommendations! Published in 2019 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izz249
Abstract: BACKGROUND Intestinal epithelial apical membrane Cl-/HCO3- exchanger DRA (downregulated in adenoma, SLC26A3) has emerged as an important therapeutic target for diarrhea, emphasizing the potential therapeutic role of agents that upregulate DRA. All-trans retinoic acid (ATRA),… read more here.
Keywords: trans retinoic; gut inflammation; dra; expression ... See more keywords
Anti-CD74 IgA antibodies show diagnostic potential for axial spondyloarthritis but are not associated with microscopic gut inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac384
Abstract: OBJECTIVES Gut inflammation commonly occurs in axial spondyloarthritis (axSpA), and is linked to disease activity and outcome. Given the role of IgA in mucosal immunity, we explored the association between anti-CD74 IgA antibodies, gut inflammation… read more here.
Keywords: anti cd74; gut inflammation; axspa; cd74 iga ... See more keywords
Infant Feeding, Gut Permeability, and Gut Inflammation Markers
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Pediatric Gastroenterology and Nutrition"
DOI: 10.1097/mpg.0000000000003756
Abstract: Objectives: Increased gut permeability and gut inflammation have been linked to the development of type 1 diabetes. Little is known on whether and how intake of different foods is linked to these mechanisms in infancy.… read more here.
Keywords: gut inflammation; gut; permeability gut; gut permeability ... See more keywords
Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16102
Abstract: Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well‐publicized guidelines for its early detection and treatment. It is recognized that the gut may aggravate… read more here.
Keywords: gut inflammation; gut; liver; toxicity ... See more keywords
OP0255 MICROBIOTA TRANSPLANT TO CONTROL INFLAMMATION IN A NLRC4-RELATED DISEASE PATIENT WITH RECURRENT HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (HLH)
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4636
Abstract: Background The NLRC4 inflammasome activation is essential in host defence, particularly against enteric pathogens. Gain-of-function mutations in NLRC4 are associated with a distinct autoinflammatory syndrome characterized by enterocolitis and recurrent HLH. Objectives To report safety… read more here.
Keywords: none declared; none; gut inflammation; hlh ... See more keywords
Pathobiome driven gut inflammation in Pakistani children with Environmental Enteric Dysfunction
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DOI: 10.1371/journal.pone.0221095
Abstract: Environmental Enteric Dysfunction (EED) is an acquired small intestinal inflammatory condition underlying high rates of stunting in children read more here.
Keywords: gut inflammation; enteric dysfunction; pathobiome driven; environmental enteric ... See more keywords
Changes in gut microbiota composition with age and correlations with gut inflammation in rats
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0265430
Abstract: Increasing evidences indicate that gut microbiota composition is associated with multiple inflammatory diseases. However, little is known about how gut microbiota changes with age and correlations with gut inflammation at sexual maturity stage of healthy… read more here.
Keywords: inflammation; gut inflammation; gut microbiota; correlations gut ... See more keywords