Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26370
Abstract: A capability for analyzing complex cellular communication among tissues is important in drug discovery and development, and in vitro technologies for doing so are required for human applications. A prominent instance is communication between the… read more here.
Keywords: gut liver; tissue; liver; crosstalk ... See more keywords
Gut–liver on a chip toward an in vitro model of hepatic steatosis
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26793
Abstract: Hepatic steatosis is a process of abnormal lipid deposition within the liver cells, often caused by excessive alcohol uptake or obesity. A conventional in vitro model for hepatic steatosis uses a liver cell culture, treated… read more here.
Keywords: liver chip; hepatic steatosis; model; gut liver ... See more keywords
Examining the gut-liver axis in liver cancer using organoid models.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.04.008
Abstract: The World Health Organization predicts that by 2030 liver cancer will cause 1 million deaths annually, thus becoming the third most lethal cancer worldwide. Hepatocellular carcinoma and cholangiocarcinoma are the two major primary cancer subtypes… read more here.
Keywords: gut liver; liver; liver axis; cancer ... See more keywords
Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids.
Sign Up to like & getrecommendations! Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.02.008
Abstract: Although the association between the microbiome and IBD and liver diseases is known, the cause and effect remain elusive. By connecting human microphysiological systems of the gut, liver, and circulating Treg and Th17 cells, we… read more here.
Keywords: gut liver; fatty acids; ibd; short chain ... See more keywords
Bisphenol A exposure induces gut microbiota dysbiosis and consequent activation of gut-liver axis leading to hepatic steatosis in CD-1 mice.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.114880
Abstract: Interactions between the intestine and the liver, the so-called 'gut-liver axis', play a crucial role in the onset of hepatic steatosis and non-alcoholic fatty liver disease. However, not much is known about the impact of… read more here.
Keywords: hepatic steatosis; gut; gut microbiota; gut liver ... See more keywords
Dendrobii Officinalis, a traditional Chinese edible and officinal plant, accelerates liver recovery by regulating the gut-liver axis in NAFLD mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.103458
Abstract: Abstract Dendrobii Officinalis (DOF) is a Traditional Chinese edible and bioavailable plant. The aim of this study was to investigate the hepatoprotective effects of DOF ultrafine powder (DOFP) and its underlying molecular mechanisms in nonalcoholic… read more here.
Keywords: mice; nafld mice; gut liver; traditional chinese ... See more keywords
Accumulation of protein-bound uremic toxins: the kidney remains the leading culprit in the gut-liver-kidney axis.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.02.026
Abstract: Protein-bound uremic toxins (PBUTs) accumulate in chronic kidney disease (CKD) and are poorly removed by dialysis. Gryp et al. demonstrated that fecal bacteria from patients with CKD do not produce more PBUTs than do those from… read more here.
Keywords: protein bound; bound uremic; uremic toxins; liver kidney ... See more keywords
The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.101091
Abstract: Metabolic syndrome (MetS) is a constellation of cardiometabolic risk factors, which together predict increased risk of more serious chronic diseases. We propose that one consequence of dietary overnutrition is increased abundance of Gram-negative bacteria in… read more here.
Keywords: gut; gut liver; metabolic syndrome; vitamin status ... See more keywords
Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut–liver axis
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the Nutrition Society"
DOI: 10.1017/s0029665118002756
Abstract: This review presents mechanistic studies performed in vitro and in animal models, as well as data obtained in patients that contribute to a better understanding of the impact of nutrients interacting with the gut microbiota… read more here.
Keywords: liver axis; metabolism; gut liver; gut microbiota ... See more keywords
Novel Strategy for Validating the Existence and Mechanism of the "gut-liver axis" in Vivo by a Hypoxia-Sensitive NIR Fluorescent Probe.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b04578
Abstract: Liver fibrosis is a major stage in the development of liver diseases and it is important to investigate its pathogenesis for early intervene or even reversing. Recent studies have found that intestinal disease can aggravate… read more here.
Keywords: gut liver; probe; liver; liver axis ... See more keywords
Propionate Ameliorates Alcohol-Induced Liver Injury in Mice via the Gut-Liver Axis: Focus on the Improvement of Intestinal Permeability.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c00633
Abstract: Alcohol-related liver disease (ALD) is a major cause of chronic liver disease worldwide with limited therapeutic options. Here, we first revealed the promising beneficial effect of gut microbiota-derived propionate on alcoholic liver injury in mice.… read more here.
Keywords: gut; injury mice; liver injury; mice ... See more keywords