Multiomics Analysis Identifies SOCS1 as Restraining T Cell Activation and Preventing Graft‐Versus‐Host Disease
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DOI: 10.1002/advs.202200978
Abstract: Graft‐versus‐host disease (GVHD) is a major life‐threatening complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Inflammatory signaling pathways promote T‐cell activation and are involved in the pathogenesis of GVHD. Suppressor of cytokine signaling 1 (SOCS1)… read more here.
Keywords: gvhd; cell activation; analysis; graft versus ... See more keywords
The association of histologic grade with acute graft‐versus‐host disease response and outcomes
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DOI: 10.1002/ajh.24749
Abstract: Consensus criteria are routinely used to clinically grade acute graft‐versus‐host disease (GVHD). A histologic grading system for acute GVHD is available, but there are limited data on its correlation with clinical grade and hematopoietic cell… read more here.
Keywords: histologic; response; grade; clinical grade ... See more keywords
Causes of early death in multiple myeloma patients treated with high-dose therapy followed by autologous stem cell transplantation: A study based on the nationwide Danish Multiple Myeloma Registry.
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DOI: 10.1002/ajh.24857
Abstract: other day for 6 doses. This was followed by a maintenance dose of 120 mg/kg IV weekly for seven weeks in responding patients. Four patients received AAT as the first therapy option after demonstrating steroid-refractory… read more here.
Keywords: therapy; multiple myeloma; steroid refractory; gvhd ... See more keywords
A population‐based study of outcomes in polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the United States from 2001 to 2015: Comparison with data from a Mayo Clinic single institutional series
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DOI: 10.1002/ajh.26377
Abstract: REFERENCES 1. Westin JR, Saliba RM, De Lima M, et al. Steroid-refractory acute GVHD: predictors and outcomes. Adv Hematol. 2011;2011:601953-601958. 2. MacMillan ML, DeFor TE, Weisdorf DJ. What predicts high risk acute graft-versus-host disease (GVHD)… read more here.
Keywords: gvhd; acute; study; host disease ... See more keywords
Long-term follow-up of a single institution pilot study of sirolimus, tacrolimus, and short course methotrexate for graft versus host disease prophylaxis in mismatched unrelated donor allogeneic stem cell transplantation
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DOI: 10.1007/s00277-018-3427-1
Abstract: Dear Editor, Allogeneic stem cell transplantation (allo-SCT) is a potentially curative treatment for patients with hematologic malignancies [1]. However, overall survival (OS) is often compromised by treatment-related complications such as graftversus-host disease (GVHD). Recipients of… read more here.
Keywords: sirolimus tacrolimus; acute gvhd; methotrexate; study ... See more keywords
Reduced risk of chronic GVHD by low-dose rATG in adult matched sibling donor peripheral blood stem cell transplantation for hematologic malignancies
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DOI: 10.1007/s00277-019-03884-8
Abstract: The optimal rabbit anti-thymocyte globulin (rATG) graft-versus-host disease (GVHD) prophylaxis regimen in matched sibling donor peripheral blood stem cell transplantation (MSD-PBSCT) remains to be elucidated. In this prospective study, we used low-dose rATG for GVHD… read more here.
Keywords: ratg; transplantation; sibling donor; gvhd ... See more keywords
Prophylaxis and treatment with mycophenolate mofetil in children with graft-versus-host disease undergoing allogeneic hematopoietic stem cell transplantation: a nationwide survey in Japan
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DOI: 10.1007/s12185-019-02601-5
Abstract: We investigated the safety and efficacy of mycophenolate mofetil (MMF) in the prevention and treatment of graft-versus-host disease (GVHD) using a nationwide retrospective survey in Japanese children undergoing hematopoietic stem cell transplantation (HSCT). Overall, 141… read more here.
Keywords: treatment; versus host; prophylaxis; gvhd ... See more keywords
A case of central nervous system graft-versus-host disease following allogeneic stem cell transplantation
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DOI: 10.1007/s12185-019-02702-1
Abstract: Graft-versus-host disease (GVHD) is a serious complication of allogeneic stem cell transplantation (SCT). Here, we report a rare case of GVHD involving the central nervous system (CNS). A 35-year-old woman was diagnosed with myelodysplastic syndrome… read more here.
Keywords: disease; cns; case; transplantation ... See more keywords
Favourable survival in “Discordant” acute gastrointestinal graft versus host disease (GI-GVHD) is explained by mild clinical course and treatment-responsive disease
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DOI: 10.1007/s12185-019-02813-9
Abstract: We have previously reported that haematopoietic progenitor cell transplantation recipients with biopsy-negative acute Gastrointestinal Graft versus Host Disease (Discordant GVHD) demonstrate superior survival compared to “True Positive” cases. We aimed to elucidate this discrepancy by… read more here.
Keywords: gastrointestinal graft; disease; true positive; acute gastrointestinal ... See more keywords
Impact of graft-versus-host disease on the clinical outcome of allogeneic hematopoietic stem cell transplantation for non-malignant diseases
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DOI: 10.1007/s12185-020-02839-4
Abstract: The impact of acute and chronic graft-versus-host disease (GVHD) on clinical outcomes was retrospectively analyzed in 960 patients with non-malignant diseases (NMD) who underwent a first allogeneic hematopoietic stem cell transplantation (HSCT). Grade III–IV acute GVHD (but not… read more here.
Keywords: associated lower; significantly associated; versus host; gvhd ... See more keywords
Soluble CD64 Is a Novel Marker of Steroid Refractory Acute Gastrointestinal Graft Versus Host Disease in Pediatric Allogeneic Hematopoietic Stem Cell Transplant
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DOI: 10.1016/j.bbmt.2018.12.263
Abstract: Background CD64 is expressed on neutrophils and monocytes and is upregulated by mediators of inflammation such as interferon-gamma, G-CSF, infection or tissue injury. Soluble CD64 is elevated in new onset Crohn's disease and is a… read more here.
Keywords: gastrointestinal graft; cd64; gvhd; soluble cd64 ... See more keywords