The Effect of ATG Exposure Based on Recipient Absolute Lymphocyte Counts in Patients Undergoing Allo-HCT with ATG and Ptcy As Gvhd Prophylaxis
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DOI: 10.1016/j.bbmt.2018.12.268
Abstract: Background Recent studies have shown that using absolute lymphocyte count (ALC) based dosing of ATG (anti-thymoglobulin) can improve survival after allogeneic hematopoietic cell transplantation (Allo–HCT). At our center we routinely use a combination of ATG + post-transplant… read more here.
Keywords: gvhd prophylaxis; atg; allo hct;
GVHD Prophylaxis Using Tacrolimus and Mini-Dose Methotrexate Improves Engraftment and Reduces Mortality in Cord Blood Transplantation
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DOI: 10.1016/j.bbmt.2018.12.289
Abstract: Background A combination of calcineurin inhibitor and methotrexate (MTX) is one of a standard GVHD prophylaxis in allogeneic hematopoietic stem cell transplantation. However, MTX delays engraftment particularly in cord blood transplantation (CBT). Methods We conducted… read more here.
Keywords: mtx; gvhd prophylaxis; mtx group; mini mtx ... See more keywords
Influence of the Intensity of the Allogeneic Conditioning Regimen on the Risk of Hemorrhagic Cystitis (HC) in Patients Receiving Post- Transplant Cyclophosphamide (PT-Cy) As Gvhd Prophylaxis
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DOI: 10.1016/j.bbmt.2018.12.441
Abstract: Background Our group previously reported a 16% incidence of HC after hematopoietic cell transplantation (HCT) involving mostly matched unrelated donors (85%) and ATG-containing regimens (80%) (Silva, Haematologica 2010). PT-Cy is an effective GVHD prophylaxis in… read more here.
Keywords: gvhd prophylaxis; conditioning regimen; cystitis; group ... See more keywords
Spectrum of Infections with a Protocol of Dual T-Lymphocyte Suppression Using ATG and PTCy for Gvhd Prophylaxis in Allogeneic Transplants for High-Risk Hematological Malignancies
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DOI: 10.1016/j.bbmt.2018.12.455
Abstract: Introduction ATG and PTCy have been individually shown to reduce rates of GVHD in allogeneic transplants. We adopted a combination regimen of ATG and PT-Cy for GVHD prophylaxis in allogenic transplants for high risk hematological… read more here.
Keywords: high risk; gvhd prophylaxis; gvhd; risk hematological ... See more keywords
Are we ready for post-transplant cyclophosphamide use in matched donor transplants?
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DOI: 10.1038/s41409-020-01204-7
Abstract: Post-transplant cyclophosphamide (PTCy) graft vs. host disease (GVHD) prophylaxis was initially developed in order to mitigate an excessive risk of acute and chronic GVHD associated with the use of haploidentical donor graft in allogeneic transplantation.… read more here.
Keywords: use; gvhd prophylaxis; group; gvhd ... See more keywords
Tacrolimus initial steady state level in post-transplant cyclophosphamide-based GvHD prophylaxis regimens
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DOI: 10.1038/s41409-021-01528-y
Abstract: Post-transplant cyclophosphamide (PTCy) combined with tacrolimus (TAC) as graft-versus-host disease (GvHD) prophylaxis post-hematopoietic cell transplantation (HCT) is safe and effective. Optimal serum levels of TAC in this combination remain undetermined. We hypothesized that TAC at… read more here.
Keywords: post transplant; gvhd prophylaxis; post; gvhd ... See more keywords
Cecal diverticulitis: Two pediatric cases
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DOI: 10.1111/ped.13940
Abstract: methotrexate (MTX) was not used for GVHD prophylaxis. The present patient developed PES followed by severe GVHD. Both high numbers of transfused cord blood cells and GVHD prophylaxis without MTX are risk factors for PES,… read more here.
Keywords: severe gvhd; gvhd prophylaxis; two pediatric; diverticulitis two ... See more keywords
Combination of ATG and Post-Transplant Cyclophosphamide for Gvhd Prophylaxis in Matched Unrelated Donor Peripheral Blood Stem Cell Transplants for High-Risk Hematological Malignancies- a Single Centre Experience
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DOI: 10.1182/blood-2018-99-111955
Abstract: Background ATG and post-transplant cyclophosphamide (PT-Cy) have been individually shown to be efficacious in reducing rates of GVHD in HLA matched and mismatched transplants. We adopted a combination regimen of ATG and PT-Cy for GVHD… read more here.
Keywords: gvhd prophylaxis; post transplant; gvhd; day ... See more keywords
Post-Transplant Cyclophosphamide for Gvhd Prophylaxis in Matched Unrelated Donor Transplantation Compared to ATG-Based Prophylaxis
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DOI: 10.1182/blood-2019-124849
Abstract: Background: Post-transplant high dose cyclophosphamide (PT-CY) effectively prevents graft-versus-host disease (GVHD) after unmanipulated HLA-haploidentical hematopoietic stem cell transplantation (HSCT). The use of PT-CY in HLA-identical donor is less explored. In this study, we analyzed the… read more here.
Keywords: gvhd prophylaxis; group; donor; atg group ... See more keywords
Combination of a Cyclophosphamide-Total Body Irradiation Conditioning Regimen and Tacrolimus Plus Mycophenolate Mofetil for Gvhd Prophylaxis Is Associated with Higher HHV-6 Encephalitis Incidence after Cord Blood Transplantation
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DOI: 10.1182/blood-2019-125209
Abstract: Background Human herpesvirus-6 (HHV-6) encephalitis occurs frequently through cord blood transplantation (CBT), and leads to a high risk of mortality and morbidity. Although CBT is a known risk factor for HHV-6 encephalitis, a thorough analysis… read more here.
Keywords: hhv encephalitis; gvhd prophylaxis; group; hhv ... See more keywords
A phase 2 trial of GVHD prophylaxis with PTCy, sirolimus, and MMF after peripheral blood haploidentical transplantation.
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DOI: 10.1182/bloodadvances.2020003779
Abstract: The introduction of posttransplant cyclophosphamide (PTCy) made performing allogeneic hematopoietic cell transplantation (HCT) from HLA haplotype-incompatible donors possible. In a setting of PTCy and tacrolimus/mycophenolate mofetil (MMF) as a graft-versus-host disease (GVHD) prophylaxis, a peripheral… read more here.
Keywords: trial; ptcy; sirolimus mmf; gvhd prophylaxis ... See more keywords