Activation of liver X receptor β-enhancing neurogenesis ameliorates cognitive impairment induced by chronic cerebral hypoperfusion
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.02.006
Abstract: ABSTRACT Chronic cerebral hypoperfusion (CCH), a leading cause of various cerebrovascular diseases, leads to cognitive dysfunction due to neuron loss and impaired neurogenesis. Liver X receptors (LXRs), including LXR&agr; and LXR&bgr; isoforms, are crucial for… read more here.
Keywords: lxr bgr; neurogenesis; gw3965; cch ... See more keywords
Akt/mTOR and AMPK signaling pathways are responsible for liver X receptor agonist GW3965-enhanced gefitinib sensitivity in nonsmall cell lung cancer cell lines
Sign Up to like & getrecommendations! Published in 2019 at "Translational cancer research"
DOI: 10.21037/26540
Abstract: Background: This study was to systemically analyze the mechanism of LXR ligand GW3965-induced sensitivity to EGFR-TKI in EGFR-TKI-resistant non-small cell lung cancer (NSCLC) cell lines. Methods: Gefitinib-resistant PC9 cell line (EGFR exon 19 deletion) was… read more here.
Keywords: akt mtor; cell; gw3965; lung cancer ... See more keywords