ComPaSS‐GWAS: A method to reduce type I error in genome‐wide association studies when replication data are not available
Sign Up to like & getrecommendations! Published in 2019 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22168
Abstract: Results from association studies are traditionally corroborated by replicating the findings in an independent data set. Although replication studies may be comparable for the main trait or phenotype of interest, it is unlikely that secondary… read more here.
Keywords: type error; association; gwas; replication ... See more keywords
CRISPR/Cas9‐Based Functional Genomics in Human Induced Pluripotent Stem Cell–Derived Models: Can “the Stars Align” for Neurodegenerative Diseases?
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.28998
Abstract: In science there are times when the concurrent development of new tools, availability of relevant models, and accessibility to large data sets can coalesce to yield unanticipated conceptual advances. Today, data from genetic studies powered… read more here.
Keywords: crispr cas9; cell; disease; gwas ... See more keywords
Genetic diversity, GWAS and prediction for drought and terminal heat stress tolerance in bread wheat (Triticum aestivum L.)
Sign Up to like & getrecommendations! Published in 2020 at "Genetic Resources and Crop Evolution"
DOI: 10.1007/s10722-020-01018-y
Abstract: Drought adversely affects crop growth, development and yield. This study assessed genetic variation in a panel of wheat lines to water deficit and identified the QTLs governing this relationship via GWAS. A panel of 290… read more here.
Keywords: stress tolerance; genetic diversity; wheat; drought ... See more keywords
Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Human Genetics"
DOI: 10.1016/j.ajhg.2018.04.011
Abstract: Causal genes and variants within genome-wide association study (GWAS) loci can be identified by integrating GWAS statistics with expression quantitative trait loci (eQTL) and determining which variants underlie both GWAS and eQTL signals. Most analyses,… read more here.
Keywords: schizophrenia; eqtl; landscape conditional; gwas ... See more keywords
Statistical methods to detect novel genetic variants using publicly available GWAS summary data
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.02.016
Abstract: We propose statistical methods to detect novel genetic variants using only genome-wide association studies (GWAS) summary data without access to raw genotype and phenotype data. With more and more summary data being posted for public… read more here.
Keywords: detect novel; summary data; statistical methods; genetic variants ... See more keywords
T13 Gwas Of Bsnip Biofactors And Biotypes As Intermediate Phenotypes For Psychosis
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2016.09.501
Abstract: Background The Bipolar and Schizophrenia Network of Intermediate Phenotypes (BSNIP) is an ongoing NIMH-funded study aimed to identify biomarker-based classification of psychoses, with clinical, imaging and neurophysiological phenotypes, consistent with Research Domain Criteria. Analyses of… read more here.
Keywords: bsnip; intermediate phenotypes; analysis; t13 gwas ... See more keywords
38 GENOME-WIDE META-ANALYSIS OF >14,000 ALCOHOL DEPENDENT INDIVIDUALS HIGHLIGHTS PSYCHIATRIC COMORBIDITIES
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.039
Abstract: Background Excessive alcohol use is a leading contributor to morbidity and mortality. 12% of drinkers meet criteria for Alcohol Dependence (AD), a serious psychiatric disorder characterized by tolerance, withdrawal, loss of control over drinking and… read more here.
Keywords: genome wide; analysis; gwas; ancestry ... See more keywords
49 LARGE-SCALE GWAS META-ANALYSIS AND MULTI-TRAIT ANALYSIS YIELDS DOZENS OF NOVEL LOCI AND NOVEL GENETIC CORRELATES FOR GENERAL COGNITIVE ABILITY
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.050
Abstract: Background Neurocognitive deficits represent a critical component of many neuropsychiatric disorders and disease states that can affect health outcomes across the lifespan. Recently, a large (N~78,000) Genome-Wide Association Studie (GWAS) reported 18 genome-wide significant loci… read more here.
Keywords: cognitive ability; analysis; gwas; loci novel ... See more keywords
Estimating the causal tissues for complex traits and diseases
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3981
Abstract: How to interpret the biological causes underlying the predisposing markers identified through genome-wide association studies (GWAS) remains an open question. One direct and powerful way to assess the genetic causality behind GWAS is through analysis… read more here.
Keywords: causal tissues; genetic causality; causality; gwas ... See more keywords
GWAS meets transcriptomics: from genetic letters to transcriptomic words of neuropsychiatric risk
Sign Up to like & getrecommendations! Published in 2020 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-020-00835-0
Abstract: Genome-wide association studies (GWAS) associate genetic variants with traits. Neuropsychiatric traits have complex etiology, and GWAS have started to reveal their polygenic architecture, including multiple single nucleotide polymorphisms (SNPs) associated with each trait (SNP-trait association—… read more here.
Keywords: risk; neuropsychiatric risk; association; expression ... See more keywords
The contributions of genetics to premature birth
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0292-0
Abstract: The human condition has many determinants. Although some of the most important are due to genetics, their fundamental contributions to various phenotypes are only apparent through gene expression. This is in large part determined by… read more here.
Keywords: hallman colleagues; risk; genetics; sptb ... See more keywords