A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-67699-8
Abstract: Genome–wide association studies (GWAS) have revealed a plethora of putative susceptibility genes for Alzheimer’s disease (AD), with the sole exception of APOE gene unequivocally validated in independent study. Considering that the etiology of complex diseases… read more here.
Keywords: genes pathways; alzheimer disease; analysis strategy; gwas analysis ... See more keywords
PGA: post-GWAS analysis for disease gene identification
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DOI: 10.1093/bioinformatics/btx845
Abstract: Summary Although the genome-wide association study (GWAS) is a powerful method to identify disease-associated variants, it does not directly address the biological mechanisms underlying such genetic association signals. Here, we present PGA, a Perl- and… read more here.
Keywords: post gwas; disease gene; disease; gwas ... See more keywords
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Sign Up to like & getrecommendations! Published in 2022 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddac158
Abstract: Abstract Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we… read more here.
Keywords: severe covid; detailed stratified; gwas analysis; analysis ... See more keywords
Phenomics‐based GWAS analysis reveals the genetic architecture for drought resistance in cotton
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DOI: 10.1111/pbi.13431
Abstract: Drought resistance (DR) is a complex trait that is regulated by a variety of genes. Without comprehensive profiling of DR-related traits, the knowledge of the genetic architecture for DR in cotton remains limited. Thus, there… read more here.
Keywords: drought resistance; analysis; genetic architecture; gwas analysis ... See more keywords
Benchmarking post-GWAS analysis tools in major depression: Challenges and implications
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1006903
Abstract: Our knowledge of complex disorders has increased in the last years thanks to the identification of genetic variants (GVs) significantly associated with disease phenotypes by genome-wide association studies (GWAS). However, we do not understand yet… read more here.
Keywords: gwas analysis; post; post gwas; major depression ... See more keywords