Multi-marker analysis of genomic annotation on gastric cancer GWAS data from Chinese populations
Sign Up to like & getrecommendations! Published in 2018 at "Gastric Cancer"
DOI: 10.1007/s10120-018-0841-y
Abstract: BackgroundGastric cancer (GC) is one of the high-incidence and high-mortality cancers all over the world. Though genome-wide association studies (GWASs) have found some genetic loci related to GC, they could only explain a small fraction… read more here.
Keywords: genomic annotation; multi marker; analysis genomic; gwas data ... See more keywords
A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
Sign Up to like & getrecommendations! Published in 2019 at "Nature neuroscience"
DOI: 10.1038/s41593-019-0382-7
Abstract: Genome-wide association studies (GWAS) have identified more than 100 schizophrenia (SCZ)-associated loci, but using these findings to illuminate disease biology remains a challenge. Here we present integrative risk gene selector (iRIGS), a Bayesian framework that… read more here.
Keywords: risk; multi omics; omics data; gwas data ... See more keywords
Simultaneous inference of phenotype-associated genes and relevant tissues from GWAS data via Bayesian integration of multiple tissue-specific gene networks
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjx059
Abstract: Although genome-wide association studies (GWAS) have successfully identified thousands of genomic loci associated with hundreds of complex traits in the past decade, the debate about such problems as missing heritability and weak interpretability has been… read more here.
Keywords: tissue specific; gene networks; specific gene; gwas data ... See more keywords
Abstract 242: Large pathway and gene set analysis of GWAS data identifies novel associations for pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-242
Abstract: Objective Genome-wide association studies (GWAS) identify associations of individual SNPs with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants has been shown for many disorders to… read more here.
Keywords: analysis gwas; analysis; gwas data; cancer ... See more keywords
Comparison of Methods Utilizing Sex-Specific PRSs Derived From GWAS Summary Statistics
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.892950
Abstract: The polygenic risk score (PRS) is calculated as the weighted sum of an individual’s genotypes and their estimated effect sizes, which is often used to estimate an individual’s genetic susceptibility to complex traits and disorders.… read more here.
Keywords: gwas data; specific prss; prs; sex ... See more keywords