Generalizability of "GWAS Hits" in Clinical Populations: Lessons from Childhood Cancer Survivors.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2020.08.014
Abstract: With mounting interest in translating genome-wide association study (GWAS) hits from large meta-analyses (meta-GWAS) in diverse clinical settings, evaluating their generalizability in target populations is crucial. Here, we consider long-term survivors of childhood cancers from… read more here.
Keywords: generalizability; gwas hits; meta gwas; childhood cancer ... See more keywords
High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of neuroinflammation"
DOI: 10.1186/s12974-025-03562-9
Abstract: Greater than a hundred genetic risk factors for Alzheimer’s disease (AD) have been identified by genome-wide association studies (GWAS), many of which are primarily expressed in microglia. However, the pathogenic role for most of them… read more here.
Keywords: alzheimer disease; disease; cluster; inflammatory ... See more keywords